Evidence map›Paper›PMID 28049733›Full record

ArticleThe Journal of biological chemistry2017

Physiological Exploration of the Long Term Evolutionary Selection against Expression of

Yuko Naito-Matsui, Leela R L Davies, Hiromu Takematsu, Hsun-Hua Chou, Pam Tangvoranuntakul, Aaron F Carlin, Andrea Verhagen, Charles J Heyser, Seung-Wan Yoo, Biswa Choudhury and 5 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 40 citations in OpenAlex.

  1. Glycosylation of the retina.Biochemical Society transactions · 2026
    Review
  2. Article
  3. Article
  4. International journal of molecular sciences · 2026
    Article
  5. Review
  6. Review
  7. Lack of significant ganglioside changes inBiochemistry and biophysics reports · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. The dynamic brain N-glycome.Glycoconjugate journal · 2022
    Review
  16. Review
  17. Article
  18. Review
  19. Spatial and temporal diversity of glycome expression in mammalian brain.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Yuko Naito-MatsuiFrom the Departments of Medicine and Cellular and Molecular Medicine.
Leela R L DaviesFrom the Departments of Medicine and Cellular and Molecular Medicine.
Hiromu TakematsuFrom the Departments of Medicine and Cellular and Molecular Medicine.
Hsun-Hua ChouFrom the Departments of Medicine and Cellular and Molecular Medicine.
Pam TangvoranuntakulFrom the Departments of Medicine and Cellular and Molecular Medicine.
Aaron F CarlinFrom the Departments of Medicine and Cellular and Molecular Medicine.
Andrea VerhagenFrom the Departments of Medicine and Cellular and Molecular Medicine.
Charles J HeyserNeuroscience Behavioral Testing Core.
Seung-Wan Yoothe Departments of Neurology and.
Biswa ChoudhuryGlycobiology Research and Training Center, and.
James C Patonthe Research Centre for Infectious Diseases, Department of Molecular and Cellular Biology, School of Biological Sciences, University of Adelaide, Adelaide SA 5005, Australia.
Adrienne W Patonthe Research Centre for Infectious Diseases, Department of Molecular and Cellular Biology, School of Biological Sciences, University of Adelaide, Adelaide SA 5005, Australia.
Nissi M VarkiDepartment of Pathology, University of California San Diego, La Jolla, California 92093-0687.
Ronald L SchnaarPharmacology and Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, and.
Ajit VarkiFrom the Departments of Medicine and Cellular and Molecular Medicine, a1varki@ucsd.edu.
La Jolla Institute For Molecular Medicine · USUniversity of California, San Diego · USUniversity of Adelaide · AUJohns Hopkins University · US

Funding

BIOSYNTHESIS AND REGULATION OF SUBSTITUTED SIALIC ACIDSR01GM032373 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI VARKI, AJIT P · 1985 to 2022
$6.9M
Complex Carbohydrates in Neuronal Cell FunctionR37NS037096 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SCHNAAR, RONALD L · 2005 to 2011
$2.8M
Brain gangliosides in learning, memory and neuronal excitabilityR21MH107965 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SCHNAAR, RONALD L · 2016 to 2017
$449k
NIGMS NIH HHS R01 GM032373NIMH NIH HHS R21 MH107965NINDS NIH HHS R37 NS037096
6 · The paper itself

Abstract

All vertebrate cell surfaces display a dense glycan layer often terminated with sialic acids, which have multiple functions due to their location and diverse modifications. The major sialic acids in most mammalian tissues are

Indexed as

Biological EvolutionAnimalsBrainChromatography, High Pressure LiquidEndothelium, VascularLocomotionMass SpectrometryMemory DisordersMiceMice, TransgenicNeuraminic AcidsNeuraminic AcidsN-glycolylneuraminic acidbacterial toxinbehaviorbraingangliosideglycobiologymyelin-associated glycoproteinN-glycolylneuraminic acidsialic acid

Identifiers

PMID28049733
PMCPMC5314156
OpenAlexW2567349123

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.