Evidence map›Paper›PMID 28049646›Full record

ReviewCold Spring Harbor perspectives in biology2017

Intermediate Filaments and the Plasma Membrane.

Jonathan C R Jones, Chen Yuan Kam, Robert M Harmon, Alexandra V Woychek, Susan B Hopkinson, Kathleen J Green

Open access · bronzeAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Junction Plakoglobin - A Dual-Role Player in Cancer Biology.International journal of surgery (London, England) · 2025
    Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Synemin Redefined: Multiple Binding Partners Results in Multifunctionality.Frontiers in cell and developmental biology · 2020
    Review
  11. Article
  12. Article
  13. Intermediate filaments and IF-associated proteins: from cell architecture to cell proliferation.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2019
    Review
  14. Kinesin-dependent transport of keratin filaments: a unified mechanism for intermediate filament transport.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  15. Overview of the Cytoskeleton from an Evolutionary Perspective.Cold Spring Harbor perspectives in biology · 2018
    Review
  16. Microtubules and Microtubule-Associated Proteins.Cold Spring Harbor perspectives in biology · 2018
    Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jonathan C R JonesThe School of Molecular Biosciences, Washington State University, Pullman, Washington 99164.
Chen Yuan KamDepartments of Dermatology and Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
Robert M HarmonDepartments of Dermatology and Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
Alexandra V WoychekThe School of Molecular Biosciences, Washington State University, Pullman, Washington 99164.
Susan B HopkinsonThe School of Molecular Biosciences, Washington State University, Pullman, Washington 99164.
Kathleen J GreenDepartments of Dermatology and Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
Northwestern University · USWashington State University · US

Funding

MOLECULAR GENETICS OF PEMPHIGUS FOLIACEUS ANTIGENR01AR041836 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Kathleen Janee Green · 1993 to 2026
$11.8M
Desmoplakin Assembly and Function in EpidermisR37AR043380 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GREEN, KATHLEEN JANEE · 2011 to 2020
$4.6M
Keratinocyte Migration and Wound HealingR01AR054184 · NIAMS · WASHINGTON STATE UNIVERSITY · PI JONES, JONATHAN C. · 2006 to 2015
$3.3M
Regulation of Desmosomal Cadherins in Oral CancerR01CA122151 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GREEN, KATHLEEN JANEE · 2006 to 2016
$2.6M
Substrate stiffness regulates alveolar epithelial cell behaviorR01HL092963 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BUDINGER, GR SCOTT, JONES, JONATHAN C. · 2009 to 2013
$1.9M
NCI NIH HHS R01 CA122151NHLBI NIH HHS R01 HL092963NIAMS NIH HHS R01 AR041836NIAMS NIH HHS R01 AR054184NIAMS NIH HHS R37 AR043380
6 · The paper itself

Abstract

A variety of intermediate filament (IF) types show intricate association with plasma membrane proteins, including receptors and adhesion molecules. The molecular basis of linkage of IFs to desmosomes at sites of cell-cell interaction and hemidesmosomes at sites of cell-matrix adhesion has been elucidated and involves IF-associated proteins. However, IFs also interact with focal adhesions and cell-surface molecules, including dystroglycan. Through such membrane interactions, it is well accepted that IFs play important roles in the establishment and maintenance of tissue integrity. However, by organizing cell-surface complexes, IFs likely regulate, albeit indirectly, signaling pathways that are key to tissue homeostasis and repair.

Indexed as

AnimalsCell AdhesionCell MembraneHomeostasisHumansIntermediate Filaments

Identifiers

PMID28049646
PMCPMC5204322
OpenAlexW2565927322

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.