ArticleTicks and tick-borne diseases2017
An insight into the sialome of Hyalomma excavatum.
Article in Ticks and tick-borne diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 45 citations in OpenAlex.
- Skin Deep: Uncovering the Early Events of Crimean-Congo Hemorrhagic Fever Virus at the Tick-Host-Virus Interface.Viruses · 2026Review
- Serpins in the Spotlight: Novel Bioinformatic Insights IntoBiochemistry research international · 2025Article
- Mining the secreted and membrane transcriptome of Hyalomma dromedarii ticks for identification of potential protective antigens.Parasites & vectors · 2024Article
- Article
- A deeper insight into the sialome of male and female Ochlerotatus triseriatus mosquitoes.Insect biochemistry and molecular biology · 2022Article
- Integrated analysis of the sialotranscriptome and sialoproteome of the rat flea Xenopsylla cheopis.Journal of proteomics · 2022Article
- Host Immune Responses to Salivary Components - A Critical Facet of Tick-Host Interactions.Frontiers in cellular and infection microbiology · 2022Review
- Article
- De novo assembled salivary gland transcriptome and expression pattern analyses for Rhipicephalus evertsi evertsi Neuman, 1897 male and female ticks.Scientific reports · 2021Article
- Transcriptomic Analysis of Salivary Glands ofFrontiers in physiology · 2021Article
- Scenes From Tick Physiology: Proteins of Sialome Talk About Their Biological Processes.Frontiers in cellular and infection microbiology · 2021Article
- Integrated analysis of sialotranscriptome and sialoproteome of the brown dog tick Rhipicephalus sanguineus (s.l.): Insights into gene expression during blood feeding.Journal of proteomics · 2020Article
- Draft genome sequences of Hirudo medicinalis and salivary transcriptome of three closely related medicinal leeches.BMC genomics · 2020Article
- Quantitative Visions of Reality at the Tick-Host Interface: Biochemistry, Genomics, Proteomics, and Transcriptomics as Measures of Complete Inventories of the Tick Sialoverse.Frontiers in cellular and infection microbiology · 2020Review
- A transcriptome-based phylogenetic study of hard ticks (Ixodidae).Scientific reports · 2019Article
- Proteomic informed by transcriptomic for salivary glands components of the camel tick Hyalomma dromedarii.BMC genomics · 2019Article
- RNA-seq analysis of the salivary glands and midgut of the Argasid tick Ornithodoros rostratus.Scientific reports · 2019Article
- The relapsing fever spirochete Borrelia turicatae persists in the highly oxidative environment of its soft-bodied tick vector.Cellular microbiology · 2019Article
- The Use of Tick Salivary Proteins as Novel Therapeutics.Frontiers in physiology · 2019Review
- De novo assembly and annotation of Hyalomma dromedarii tick (Acari: Ixodidae) sialotranscriptome with regard to gender differences in gene expression.Parasites & vectors · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Tick saliva contains hundreds or thousands of proteins that help blood feeding by impairing their hosts' hemostasis, inflammation and immunity. Salivary gland transcriptomes allow the disclosure of this pharmacologically active potion that consists of several multi-gene families, many of which are tick-specific. We here report the "de novo" assembly of ∼138 million reads deriving from a cDNA library from salivary glands of adult male and female Hyalomma excavatum leading to the public deposition of 5337 coding sequences to GenBank. Among the deducted putative secreted proteins, metalloproteases, glycine rich proteins, mucins, anticoagulants of the madanin family and lipocalins were the most expressed. Novel protein families were identified. These sequences will permit proteomic studies aiming at identification of target antigens, epidemiological markers or salivary pharmaceuticals of interest, and contribute to our understanding of the fast evolution of the tick sialome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.