Evidence map›Paper›PMID 28049566›Full record

SynthesisBiological psychiatry2017

An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype.

Nese Direk, Stephanie Williams, Jennifer A Smith, Stephan Ripke, Tracy Air, Azmeraw T Amare, Najaf Amin, Bernhard T Baune, David A Bennett, Douglas H R Blackwood and 92 more

Open access · greenAbstract readMeta-Analysis
In one paragraph

Synthesis in Biological psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 6 pooled it
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 6 syntheses or guidelines pooled it, 96 citations in OpenAlex.

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  4. Imaging genetics paradigms in depression research: Systematic review and meta-analysis.Progress in neuro-psychopharmacology & biological psychiatry · 2018
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

102 authors at 20 institutions in 17 countries.

Nese DirekDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam; Department of Psychiatry, Dokuz Eylul University, Izmir, Turkey.
Stephanie WilliamsDepartment of Genetics, Genomic Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Jennifer A SmithDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan.
Stephan RipkeStanley Center for Psychiatric Research, The Broad Institute of Harvard and MIT, Cambridge; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston; Department of Psychiatry and Psychotherapy, Charité, Campus Mitte, Berlin.
Tracy AirDiscipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia.
Azmeraw T AmareDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen; Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia.
Najaf AminGenetic Epidemiology Unit, Erasmus University Medical Center, Rotterdam.
Bernhard T BauneDiscipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia.
David A BennettRush Alzheimer's Disease Center & Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois.
Douglas H R BlackwoodDivision of Psychiatry, University of Edinburgh, Edinburgh.
Dorret BoomsmaDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands.
Gerome BreenMRC Social, Genetic & Developmental Psychiatry Centre Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London.
Henriette N ButtenschønTranslational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus.
Enda M ByrneQueensland Brain Institute, University of Queensland, St. Lucia, Queensland.
Anders D BørglumDepartment of Biomedicine and Centre for Integrative Sequencing, Aarhus University, Aarhus; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus.
Enrique CastelaoDepartment of Psychiatry, Lausanne University Hospital, Lausanne.
Sven CichonInstitute of Human Genetics, University of Bonn, Bonn; Department of Genomics, Life & Brain Center, Bonn; Institute of Neuroscience and Medicine, Research Centre Jülich, Jülich; Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.
Toni-Kim ClarkeDivision of Psychiatry, University of Edinburgh, Edinburgh.
Marilyn C CornelisDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Udo DannlowskiDepartment of Psychiatry and Psychotherapy, University of Münster, Münster.
Philip L De JagerProgram in Medical and Population Genetics, The Broad Institute of Harvard and MIT, Cambridge; Department of Neurology, Program in Translational NeuroPsychiatric Genomics, Brigham and Women's Hospital, Harvard Medical School, Boston; Department of Neurology, Harvard Medical School, Boston.
Ayse DemirkanGenetic Epidemiology Unit, Erasmus University Medical Center, Rotterdam.
Enrico DomeniciRoche Pharmaceutical Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases Discovery & Translational Medicine Area, Roche Innovation Center Basel, F Hoffman-La Roche Ltd., Basel, Switzerland; Centre for Integrative Biology, University of Trento, Trento, Italy.
Cornelia M van DuijnGenetic Epidemiology Unit, Erasmus University Medical Center, Rotterdam.
Erin C DunnStanley Center for Psychiatric Research, The Broad Institute of Harvard and MIT, Cambridge; Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston; Department of Psychiatry, Harvard Medical School, Boston.
Johan G ErikssonNational Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki; Department of General Practice and Primary Health Care, University of Helsinki, Helsinki; Unit of General Practice, Helsinki University Central Hospital, Helsinki; Folkhalsan Research Centre, Helsinki; Vasa Central Hospital, Vasa, Finland.
Tonu EskoProgram in Medical and Populational Genetics, The Broad Institute of Harvard and MIT, Cambridge; Division of Endocrinology, Boston Children's Hospital, Cambridge; Department of Genetics, Harvard Medical School, Boston; Estonian Genome Center, University of Tartu, Tartu, Estonia.
Jessica D FaulInstitute for Social Research, University of Michigan, Ann Arbor, Michigan.
Luigi FerrucciTranslational Gerontology Branch, National Institute on Aging, Baltimore, Maryland.
Myriam FornageBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas.
Eco de GeusDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands.
Michael GillDepartment of Psychiatry, Trinity Centre for Health Science, Dublin, Ireland.
Scott D GordonQIMR Berghofer Medical Research Institute, Brisbane.
Hans Jörgen GrabeDepartment of Psychiatry and Psychotherapy, Helios Hospital Stralsund, Munich; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Munich; German Center for Neurodegenerative Diseases, Site Rostock/Greifswald, Munich.
Gerard van GrootheestDepartment of Psychiatry, Neuroscience Campus Amsterdam and EMGO Institute of Health and Care Research, VU University, Amsterdam, The Netherlands.
Steven P HamiltonDepartment of Psychiatry, Kaiser Permanente San Francisco Medical Center, San Francisco.
Catharina A HartmanDepartment of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen.
Andrew C HeathDepartment of Psychiatry, Washington University, St. Louis, Missouri.
Karin HekDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam; Department of Psychiatry, Erasmus University Medical Center, Rotterdam.
Albert HofmanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam.
Georg HomuthInterfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Munich.
Carsten HornRoche Pharmaceutical Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases Discovery & Translational Medicine Area, Roche Innovation Center Basel, F Hoffman-La Roche Ltd., Basel, Switzerland.
Jouke Jan HottengaDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands.
Sharon L R KardiaDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan.
Stefan KloiberMax Planck Institute of Psychiatry, Munich.
Karestan KoenenDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.
Zoltán KutalikInstitute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne.
Karl-Heinz LadwigDepartment of Psychosomatic Medicine and Psychotherapy, Klinikum rechts der Isar, Technische Universität München, Munich; Institute of Epidemiology II, Mental Health Research Unit, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg.
Jari LahtiFolkhalsan Research Centre, Helsinki; Institute of Behavioural Sciences, University of Helsinki, Helsinki.
Douglas F LevinsonDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California.
Cathryn M LewisMRC Social, Genetic & Developmental Psychiatry Centre Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London.
Glyn LewisDivision of Psychiatry, University College London, London.
Qingqin S LiJanssen Research & Development LLC, New Brunswick, New Jersey.
David J LlewellynUniversity of Exeter Medical School, Exeter.
Susanne LucaeMax Planck Institute of Psychiatry, Munich.
Kathryn L LunettaDepartment of Biostatistics, Boston University School of Public Health, Framingham, Massachusetts; Boston University and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts.
Donald J MacIntyreDivision of Psychiatry, University of Edinburgh, Edinburgh.
Pamela MaddenDepartment of Psychiatry, Washington University, St. Louis, Missouri.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane.
Andrew M McIntoshDivision of Psychiatry, University of Edinburgh, Edinburgh.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu, Estonia; Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
Yuri MilaneschiDepartment of Psychiatry, Neuroscience Campus Amsterdam and EMGO Institute of Health and Care Research, VU University, Amsterdam, The Netherlands.
Grant W MontgomeryQIMR Berghofer Medical Research Institute, Brisbane.
Ole MorsThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus; Research Department P, Aarhus University Hospital, Risskov, Denmark.
Thomas H MosleyDepartment of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
Joanne M MurabitoDepartment of Medicine, Section of General Internal Medicine, Boston University School of Medicine, Boston; Boston University and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts.
Bertram Müller-MyhsokMax Planck Institute of Psychiatry, Munich; Munich Cluster for Systems Neurology, Munich; University of Liverpool, Institute of Translational Medicine, Liverpool.
Markus M NöthenInstitute of Human Genetics, University of Bonn, Bonn; Department of Genomics, Life & Brain Center, Bonn.
Dale R NyholtQIMR Berghofer Medical Research Institute, Brisbane; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland.
Michael C O'DonovanMRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Brenda W PenninxDepartment of Psychiatry, Neuroscience Campus Amsterdam and EMGO Institute of Health and Care Research, VU University, Amsterdam, The Netherlands.
Michele L PergadiaDepartment of Psychiatry, Washington University, St. Louis, Missouri; Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida.
Roy PerlisCenter for Experimental Drugs and Diagnostics, Massachusetts General Hospital and Harvard Medical School, Boston.
James B PotashDepartment of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Martin PreisigDepartment of Psychiatry, Lausanne University Hospital, Lausanne.
Shaun M PurcellDivision of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.
Jorge A QuirozSolid GT, Boston; Roche Pharmaceutical Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases Discovery & Translational Medicine Area, Roche Innovation Center Basel, F Hoffman-La Roche Ltd., Basel, Switzerland.
Katri RäikkönenInstitute of Behavioural Sciences, University of Helsinki, Helsinki.
John P RiceDepartment of Psychiatry, Washington University, St. Louis, Missouri.
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim.
Margarita RiveraMRC Social, Genetic & Developmental Psychiatry Centre Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London; CIBERSAM-Universidad de Granada, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain.
Thomas G SchulzeInstitute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University, Munich; Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Germany.
Jianxin ShiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Stanley ShynGroup Health, Seattle, Washington.
Grant C SinnamonDepartment of Psychiatry and Psychiatric Neuroscience, School of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia.
Johannes H SmitDepartment of Psychiatry, Neuroscience Campus Amsterdam and EMGO Institute of Health and Care Research, VU University, Amsterdam, The Netherlands.
Jordan W SmollerStanley Center for Psychiatric Research, The Broad Institute of Harvard and MIT, Cambridge; Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston; Department of Psychiatry, Harvard Medical School, Boston.
Harold SniederUnit of Genetic Epidemiology & Bioinformatics, University Medical Center Groningen, University of Groningen, Groningen.
Toshiko TanakaTranslational Gerontology Branch, National Institute on Aging, Baltimore, Maryland.
Katherine E TanseyMRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Munich.
Rudolf UherMRC Social, Genetic & Developmental Psychiatry Centre Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London; Dalhousie University, Halifax, Nova Scotia, Canada.
Daniel UmbrichtRoche Pharmaceutical Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases Discovery & Translational Medicine Area, Roche Innovation Center Basel, F Hoffman-La Roche Ltd., Basel, Switzerland.
Sandra Van der AuweraDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Munich; German Center for Neurodegenerative Diseases, Site Rostock/Greifswald, Munich.
Erin B WareDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan; Institute for Social Research, University of Michigan, Ann Arbor, Michigan.
David R WeirInstitute for Social Research, University of Michigan, Ann Arbor, Michigan.
Myrna M WeissmanCollege of Physicians and Surgeons, Columbia University and New York State Psychiatric Institute, New York, New York.
Gonneke WillemsenDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands.
Jingyun YangRush Alzheimer's Disease Center & Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois.
Wei ZhaoDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan.
Henning TiemeierDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam; Department of Psychiatry, Erasmus University Medical Center, Rotterdam. Electronic address: h.tiemeier@erasmusmc.nl.
Patrick F SullivanDepartment of Psychiatry, Genomic Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Center for Psychiatric Genomics, Genomic Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden.
Erasmus MC · NLUniversity of Michigan · USBroad Institute · USAmsterdam Neuroscience · NLRoche (Switzerland) · CHUniversity of Edinburgh · GBWashington University in St. Louis · USQIMR Berghofer Medical Research Institute · AUUniversitätsmedizin Greifswald · DEUniversity Medical Center Groningen · NLUniversity of Helsinki · FIBoston University · USCardiff University · GBKing's College London · GBMax Planck Institute of Psychiatry · DENational Institute on Aging · USRush University Medical Center · USThe University of Adelaide · AUUniversity of Bonn · DEUniversity of Lausanne · CH

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8M
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BARNES, LISA L · 1991 to 2020
$49.1M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4M
A Large-Scale Schizophrenia Association Study in SwedenR01MH077139 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2007 to 2018
$9.9M
Creating a National Resource for Genetic Research in Behavioral & Health SciencesRC2AG036495 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WEIR, DAVID R. · 2009 to 2010
$7.4M
Integration of Genomics & Transcriptomics in Normal Twins & Major DepressionRC2MH089951 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2009 to 2010
$6.5M
Expanding a National Resource for Genetic Research in Behavioral & Health ScienceRC4AG039029 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WEIR, DAVID R. · 2010 to 2010
$6.0M
Risk Factors, Pathology, and Clinical Expressions of ADRF1AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2014 to 2014
$6.0M
The Aging Genome Association Study "AGE-GAIN"ZIAAG000965 · NIA · NATIONAL INSTITUTE ON AGING · PI FERRUCCI, LUIGI · 2009 to 2025
$4.0M
Genomics of Developmental Trajectories in TwinsRC2MH089995 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUDZIAK, JAMES J. · 2009 to 2010
$3.8M
Department of HealthMedical Research Council G0200243Medical Research Council G0701420Medical Research Council MR/K026992/1NIA NIH HHS P30 AG010161NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS RC2 AG036495NIA NIH HHS RC4 AG039029NIA NIH HHS RF1 AG015819NIA NIH HHS U01 AG009740NIMH NIH HHS K01 MH102403NIMH NIH HHS R01 MH077139NIMH NIH HHS R01 MH081802NIMH NIH HHS R01 MH095034NIMH NIH HHS RC2 MH089951NIMH NIH HHS RC2 MH089995NIMH NIH HHS U01 MH094421NIMH NIH HHS U01 MH109528NIMH NIH HHS U24 MH068457Wellcome Trust 076113Wellcome Trust 085475Wellcome Trust 090355Wellcome Trust 104036
6 · The paper itself

Abstract

backgroundThe genetics of depression has been explored in genome-wide association studies that focused on either major depressive disorder or depressive symptoms with mostly negative findings. A broad depression phenotype including both phenotypes has not been tested previously using a genome-wide association approach. We aimed to identify genetic polymorphisms significantly associated with a broad phenotype from depressive symptoms to major depressive disorder.

methodsWe analyzed two prior studies of 70,017 participants of European ancestry from general and clinical populations in the discovery stage. We performed a replication meta-analysis of 28,328 participants. Single nucleotide polymorphism (SNP)-based heritability and genetic correlations were calculated using linkage disequilibrium score regression. Discovery and replication analyses were performed using a p-value-based meta-analysis. Lifetime major depressive disorder and depressive symptom scores were used as the outcome measures.

resultsThe SNP-based heritability of major depressive disorder was 0.21 (SE = 0.02), the SNP-based heritability of depressive symptoms was 0.04 (SE = 0.01), and their genetic correlation was 1.001 (SE = 0.2). We found one genome-wide significant locus related to the broad depression phenotype (rs9825823, chromosome 3: 61,082,153, p = 8.2 × 10

conclusionsThis large study identified a new locus for depression. Our results support a continuum between depressive symptoms and major depressive disorder. A phenotypically more inclusive approach may help to achieve the large sample sizes needed to detect susceptibility loci for depression.

Indexed as

Genetic LociGenetic Predisposition to DiseaseAcid Anhydride HydrolasesBis(5'-adenosyl)triphosphataseDepressionDepressive DisorderGenome-Wide Association StudyHumansNeoplasm ProteinsPhenotypeWhite PeopleAcid Anhydride HydrolasesBis(5'-adenosyl)triphosphataseNeoplasm ProteinsCHARGE consortiumDepressive symptomsFHIT geneGenome-wide association studyMajor depressive disorderPsychiatric Genomics Consortium

Identifiers

PMID28049566
PMCPMC5462867
OpenAlexW2560318205

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.