Evidence map›Paper›PMID 28049555›Full record

ReviewAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2017

FOXP3-Positive Regulatory T Cells and Kidney Allograft Tolerance.

Alessandro Alessandrini, Laurence A Turka

Abstract readReview
In one paragraph

Review in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Immune Landscape in Kidney Transplantation.Journal of inflammation research · 2025
    Review
  6. Article
  7. Review
  8. RNA expression profiling of nonhuman primate renal allograft rejection identifies tolerance.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018
    Article
  9. Advances in the immunology of heart transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2017
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alessandro AlessandriniCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA. Electronic address: alessand@helix.mgh.harvard.edu.
Laurence A TurkaCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA. Electronic address: lturka@partners.org.
Massachusetts General Hospital · US

Funding

XENOGENIC TOLERANCE IN MICEP01HL018646 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 1985 to 2019
$37.5M
T Cell Fate as a Determinant of Alloimmune ResponsesP01AI041521 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI STROM, TERRY B. · 1997 to 2011
$15.9M
Project 3: The Role of Erythropoietin in Kidney Transplant ToleranceP01AI123086 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 2016 to 2020
$10.6M
TOLERANCE INDUCTION BY DST PLUS COSTIMULATORY BLOCKADER01AI037691 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI TURKA, LAURENCE A · 1995 to 2015
$5.3M
NHLBI NIH HHS P01 HL018646NIAID NIH HHS P01 AI041521NIAID NIH HHS P01 AI123086NIAID NIH HHS R01 AI037691
6 · The paper itself

Abstract

Normal immune homeostasis is achieved by several mechanisms, and prominent among them is immunoregulation. Although several types of regulatory lymphocyte populations have been described, CD4 T cells expressing the FOXP3 transcription factor (FOXP3-positive regulatory T cells [FOXP3

Indexed as

Kidney TransplantationAutoantigensForkhead Transcription FactorsGraft RejectionHumansImmunosuppressive AgentsImmunotherapy, AdoptiveIsoantigensKidney Failure, ChronicSelf ToleranceT-Lymphocytes, RegulatoryTransplantation ToleranceAutoantigensForkhead Transcription FactorsFOXP3 protein, humanImmunosuppressive AgentsIsoantigenscellular therapyend-stage renal disease (ESRD)Foxp3(+) Tregsimmunoregulationimmunotherapykidney allograftskidney transplant toleranceRegulatory T cellsrenal transplantationreviewself-tolerancetransplant tolerance

Identifiers

PMID28049555
PMCPMC5403573
OpenAlexW2563889974

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.