ArticleRadiation oncology (London, England)2017
Risk of second cancer following radiotherapy for prostate cancer: a population-based analysis.
Article in Radiation oncology (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prostate radiotherapy and the risk of secondary rectal cancer-a meta-analysis.International journal of colorectal disease · 2022Pooled it
- Risk of secondary rectal cancer and colon cancer after radiotherapy for prostate cancer: a meta-analysis.International journal of colorectal disease · 2018Pooled it
- Effects of Radiation Therapy on the Incidence of Bladder Cancer and Rectal Cancer in Patients with Prostate Cancer: A Nationwide Nested Case-Control Study in Korean Population.The world journal of men's health · 2026Article
- Does Race/Ethnicity Affect Secondary Bladder and Rectal Cancer Rates After Prostate Cancer Radiation? Results from a Population-Based Study.Journal of racial and ethnic health disparities · 2026Article
- Corrective and Restorative Dermatology in Cancer Survivors: An Urgent Unmet Need!American journal of clinical dermatology · 2026Review
- Factors Associated With Male Breast Cancer Incidence Among Prostate Cancer Survivors: Real World Evidence From Veterans Affairs National Prostate Cancer Data Core.The Prostate · 2026Article
- Risk factors for secondary bladder cancer following prostate cancer radiotherapy.Translational andrology and urology · 2024Review
- The impact of baseline health factors on second primary cancer risk after radiotherapy for prostate cancer.Acta oncologica (Stockholm, Sweden) · 2024Article
- Skin Malignancies Due to Anti-Cancer Therapies.Cancers · 2024Review
- Association of radiotherapy for prostate cancer and second primary colorectal cancer: a US population-based analysis.Techniques in coloproctology · 2023Article
- Risk of secondary malignancy following radiation therapy for prostate cancer.Scientific reports · 2023Article
- The Current Trend of Radiation Therapy for Patients with Localized Prostate Cancer.Current oncology (Toronto, Ont.) · 2023Review
- Clinical outcomes and treatment patterns in REASSURE: planned interim analysis of a real-world observational study of radium-223 in metastatic castration-resistant prostate cancer.EClinicalMedicine · 2023Article
- Incidence risk assessment of secondary cancer due to radiotherapy of women with rectal cancer using BEIR VII, EPA, and ICRP models.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2023Article
- Risk and prognosis of secondary bladder cancer after post-operative radiotherapy for gynecological cancer.Bosnian journal of basic medical sciences · 2022Article
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- Racial differences in the risk of second primary bladder cancer following radiation therapy among localized prostate cancer patients.Cancer epidemiology · 2021Article
- Risk of second cancer among young prostate cancer survivors.Radiation oncology journal · 2021Article
- Urological complications after radiation therapy-nothing ventured, nothing gained: a Narrative Review.Translational cancer research · 2021Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate the risk of second cancer and radiation induced second cancer following prostate cancer radiotherapy.
methodsWe compared men with radiotherapy only with those treated with radical prostatectomy only and those with radiotherapy after radical prostatectomy. Cumulative incidences of second cancers were calculated. Cox analyses were performed to identify determinants influencing second cancer incidence.
resultsNineteen thousand five hundred thirty eight patients were analyzed. Age and median follow-up differed significantly with radiotherapy only patients having the highest median age (70.3 years) and radical prostatectomy only patients the longest median follow-up (10.2 years). Ten-year cumulative incidence of second cancer was 15.9%, 13.2% and 10.5% for patients with radiotherapy only, radiotherapy after radical prostatectomy and radical prostatectomy only (p <0.0001). Increasing age and belonging to the radiotherapy only group were associated with a higher risk of second cancer-no significant increase was seen in radiotherapy after radical prostatectomy patients. A significantly higher rate of smoking related malignancies, like lung, bladder and non-melanoma skin cancer, was seen in radiotherapy only patients.
conclusionsNo clear increase in radiation induced second cancer was found in patients after radiotherapy for prostate cancer. Whereas the rate of second cancer was increased in radiotherapy only patients, no such increase was seen in patients with radiotherapy after radical prostatectomy. The increase of second cancer following radiotherapy only is highly likely to reflect advanced age and lifestyle habits and comorbidities.
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