ArticleBMC medicine2017
Unraveling the associations of age and menopause with cardiovascular risk factors in a large population-based study.
Article in BMC medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 63 papers, 2 of them syntheses that pooled it.
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Who cites it
63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 144 citations in OpenAlex.
- Pooled it
- Association between HDL-C levels and menopause: a meta-analysis.Hormones (Athens, Greece) · 2021Pooled it
- Reproductive lifespan in relation to diabetes mellitus and metabolic syndrome in a nationally representative population.BMJ open diabetes research & care · 2026Article
- Observational
- Obesity and female reproductive health in Asian population.Obesity pillars · 2026Review
- Cardiovascular Health Characterization Using Life's Essential 8 Score in Perimenopausal Women: An Analysis of the National Health and Nutritional Examination Survey.Journal of the American Heart Association · 2026Article
- Adverse Cardiometabolic Impacts of Sleep Fragmentation and Estradiol Suppression: An Experimental Model of Menopause.The Journal of clinical endocrinology and metabolism · 2026Article
- Physical activity partners for women with cardiovascular disease risk: Proof-of-concept trial with daily assessment.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- Hormone replacement therapy and cardiovascular risk in postmenopausal women.European heart journal open · 2026Review
- The influence of menopausal phase on atrial fibrillation risk in steatotic liver disease patients: a nationwide cohort study.Scientific reports · 2026Article
- Preferences and responses for physical activity partnerships among women in midlife with elevated risk for cardiovascular disease: a digital, mixed methods approach.Psychology & health · 2025Article
- Longitudinal changes in metabolism-related metrics and breast cancer risk: a general population study.Breast cancer research : BCR · 2025Article
- The Particularities of Arterial Hypertension in Female Sex: From Pathophysiology to Therapeutic Management.Journal of clinical medicine · 2025Review
- Extremely High Systemic Immune Inflammation Levels Increase the Risk of All-Cause and Cardiovascular Mortality in Postmenopausal Women.International journal of women's health · 2025Article
- Incorporating reproductive system history data into cardiovascular nursing research to advance women's health.European journal of cardiovascular nursing · 2024Article
- The impact of reproductive factors on the metabolic profile of females from menarche to menopause.Nature communications · 2024Article
- Resolution of inflammation in chronic disease via restoration of the heat shock response (HSR).Cell stress & chaperones · 2024Review
- Association between the aromatase (Archives of endocrinology and metabolism · 2024Article
- Gender-Related Factors in Medication Adherence for Metabolic and Cardiovascular Health.Metabolites · 2023Review
- Impact of menopausal symptoms on work and careers: a cross-sectional study.Occupational medicine (Oxford, England) · 2023Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the association between menopause and cardiovascular disease (CVD) risk has been studied extensively, the simultaneous role of chronological aging herein remains underexposed. This study aims to disentangle the relationships of menopausal status and chronological aging with CVD risk factors in the largest study population to date.
methodsIn this cross-sectional study, CVD risk factors were compared between women with a different menopausal status within the same yearly age strata. The study population comprised female participants of the baseline visit of the population-based LifeLines Cohort Study. A total of 63,466 women, aged between 18 and 65 years, was included. Of them, 39,379 women were considered to be premenopausal, 8669 were perimenopausal, 14,514 were naturally postmenopausal, and 904 were surgically postmenopausal.
resultsCompared to postmenopausal women aged 45 years, average total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-c) were 0.5 and 0.4 mmol/L higher, respectively, in postmenopausal women aged 50. Systolic and diastolic blood pressure levels were 4 and 1 mmHg higher, respectively. At all ages between 46 and 55 years, and after adjustment for confounders, naturally postmenopausal women had 0.2 to 0.4 mmol/L higher TC and 0.1 to 0.3 mmol/L higher LDL-c levels compared to premenopausal women in the same age range. Systolic blood pressure levels were up to 4 mmHg lower in naturally post- compared to premenopausal women at all ages between 29 and 52 years. Body mass index levels were up to 3.2 kg/m
conclusionsChronological age and menopausal status are both independently associated with CVD risk factors. Based on the comparatively smaller observed differences associated with menopausal status than with chronological aging, the significance of a more unfavorable lipid profile in a later reproductive stage may be less obvious than previously thought.
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