Evidence map›Paper›PMID 28049214›Full record

ReviewSeminars in reproductive medicine2017

Relating Chronic Pelvic Pain and Endometriosis to Signs of Sensitization and Myofascial Pain and Dysfunction.

Jacqueline V Aredo, Katrina J Heyrana, Barbara I Karp, Jay P Shah, Pamela Stratton

3 registry-linked trialsAbstract readReview
In one paragraph

Review in Seminars in reproductive medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 99 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 6 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05418751 nacompletednot on this mapstarted 2021, after this paper: background citation

Effectiveness of a Manual Therapy Protocol on Women With Pelvic Pain Due to Endometriosis: a Randomised Clinical Trial

TypeinterventionalSponsorUniversity of ValenciaRan2021 to 2023Enrolled40ConditionsEndometriosis, Pelvic PainArmsManual therapy, Placebo treatment
NCT05851742 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effects of Myofascial Release With and Without Electrical Stimulation on Pain and Functionality in Women With Chronic Pelvic Pain

TypeinterventionalSponsorRiphah International UniversityRan2023 to 2023Enrolled24ConditionsChronic Pelvic Pain, Myofascial Trigger Point PainArmsTENS, Myofascial trigger point release
NCT06795243 narecruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy of Physical Therapy Treatment in Endometriosis and Its Relationship to Adherence Rates.

TypeinterventionalSponsorUniversity of SevilleRan2025 to 2026Enrolled32ConditionsEndometriosis, Endometriosis Related Pain, Endometriosis, Pain, Endometriosis-related PainArmsPAIN NEUROSCIENCE EDUCATION AND THERAPEUTIC EXERCISE PROGRAM, USUAL CARE
3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 6 syntheses or guidelines pooled it, 224 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Altered Blood Pressure Reflexes in Women With Endometriosis.Hypertension (Dallas, Tex. : 1979) · 2025
    Trial
  9. Trial
  10. Trial
  11. Review
  12. Review
  13. Observational
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jacqueline V AredoNational Institute of Neurological Disorders and Stroke, Clinical Center, Intramural Research Program NIH, Bethesda, Maryland.
Katrina J HeyranaDepartment of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, New York.
Barbara I KarpNational Institute of Neurological Disorders and Stroke, Clinical Center, Intramural Research Program NIH, Bethesda, Maryland.
Jay P ShahRehabilitation Medicine Department, Clinical Center, Intramural Research Program NIH, Bethesda, Maryland.
Pamela StrattonNational Institute of Neurological Disorders and Stroke, Clinical Center, Intramural Research Program NIH, Bethesda, Maryland.
National Institute of Neurological Disorders and Stroke · USOffice of Extramural Research · USUniversity of Rochester Medical Center · US

Funding

The effectiveness of Botulinum toxin on persistent pelvic pain in women with endometriosisZIANS003159 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI STRATTON, PAMELA · 2017 to 2025
$643k
Neural Immune and Genetic Influences on Chronic Pelvic Pain and EndometriosisZIANS003158 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI STRATTON, PAMELA · 2017 to 2025
$241k
Intramural NIH HHS Z99 NS999999
6 · The paper itself

Abstract

Chronic pelvic pain is a frustrating symptom for patients with endometriosis and is frequently refractory to hormonal and surgical management. While these therapies target ectopic endometrial lesions, they do not directly address pain due to central sensitization of the nervous system and myofascial dysfunction, which can continue to generate pain from myofascial trigger points even after traditional treatments are optimized. This article provides a background for understanding how endometriosis facilitates remodeling of neural networks, contributing to sensitization and generation of myofascial trigger points. A framework for evaluating such sensitization and myofascial trigger points in a clinical setting is presented. Treatments that specifically address myofascial pain secondary to spontaneously painful myofascial trigger points and their putative mechanisms of action are also reviewed, including physical therapy, dry needling, anesthetic injections, and botulinum toxin injections.

Indexed as

Central Nervous System SensitizationAnalgesicsAnestheticsBotulinum ToxinsChronic PainEndometriosisFemaleHumansInjectionsMyofascial Pain SyndromesNeural PathwaysPain MeasurementPain PerceptionPain ThresholdPelvic PainPhysical Therapy ModalitiesAnalgesicsAnestheticsBotulinum Toxins

Identifiers

PMID28049214
PMCPMC5585080
OpenAlexW2567532748

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.