Evidence map›Paper›PMID 28049128›Full record

ReviewEuropean respiratory review : an official journal of the European Respiratory Society2017

Immune reconstitution inflammatory syndrome associated with pulmonary pathogens.

Radha Gopal, Rekha R Rapaka, Jay K Kolls

Open access · diamondAbstract readReview
In one paragraph

Review in European respiratory review : an official journal of the European Respiratory Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Radha GopalRichard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA.
Rekha R RapakaDivision of Infectious Diseases and Center for Vaccine Development, University of Maryland Medical Center, Baltimore, MD, USA.
Jay K KollsRichard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA Jay.Kolls@chp.edu.
Children's Hospital of Pittsburgh · USRichard King Mellon Foundation · USUniversity of Maryland Medical Center · US

Funding

Translational StudiesP30DK072506 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FRIZZELL, RAYMOND A · 2005 to 2017
$12.5M
FELLOWSHIP TRAINING PROGRAM IN VACCINOLOGYT32AI007524 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Marcelo B. Sztein · 1997 to 2026
$6.4M
Th17 Cytokines and Lung ImmunityR37HL079142 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOLLS, JAY K · 2010 to 2017
$3.6M
Determinants of antibody-based host resistance against Pneumocystis cariniiF30ES015413 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAPAKA, REKHA R · 2006 to 2009
$157k
NHLBI NIH HHS R37 HL079142NIAID NIH HHS T32 AI007524NIDDK NIH HHS P30 DK072506NIEHS NIH HHS F30 ES015413
6 · The paper itself

Abstract

Immune reconstitution inflammatory syndrome (IRIS) is an exaggerated immune response to a variety of pathogens in response to antiretroviral therapy-mediated recovery of the immune system in HIV-infected patients. Although IRIS can occur in many organs, pulmonary IRIS, associated with opportunistic infections such as Mycobacterium tuberculosis and Pneumocystis jirovecii, is particularly associated with high morbidity and mortality. The pathology of IRIS is associated with a variety of innate and adaptive immune factors, including CD4

Indexed as

Adaptive ImmunityImmunity, InnateAnimalsCytokinesDisease Models, AnimalHost-Pathogen InteractionsHumansImmune Reconstitution Inflammatory SyndromeInflammation MediatorsLymphocyte SubsetsMice, KnockoutPrimatesPrognosisRespiratory Tract InfectionsSignal TransductionToll-Like ReceptorsCytokinesInflammation MediatorsToll-Like Receptors

Identifiers

PMID28049128
PMCPMC5642276
OpenAlexW2573259909

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.