ArticleJournal of affective disorders2017
Depressive symptom composites associated with cortisol stress reactivity in adolescents.
Article in Journal of affective disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Cortisol and development of depression in adolescence and young adulthood - a systematic review and meta-analysis.Psychoneuroendocrinology · 2022Pooled it
- Early-life adversity and cortisol response to social stress: a meta-analysis.Translational psychiatry · 2017Pooled it
- Stress-induced cortisol reactivity as a predictor of success in treatment for affective dimensions.Psychoneuroendocrinology · 2020Trial
- Wild Flora Species from Romania with Anxiolytic and Antidepressant Potential: A Global Perspective-Narrative Review.Biomedicines · 2026Review
- Cortisol and C-reactive protein interact to predict depressive symptoms.Psychoneuroendocrinology · 2026Article
- Inhibitory control and stress biomarkers in response to social media stimuli: a Go/No-Go study using heart rate variability, alpha-amylase and oxytocin.Frontiers in psychiatry · 2026Article
- Social buffering by siblings in childhood and adolescence.Psychoneuroendocrinology · 2025Article
- Anti-fatigue effects of Korean Red Ginseng extract in healthy Japanese adults: A randomized, double-blind, placebo-controlled study.Journal of ginseng research · 2025Article
- Gender differences of neurometabolic and neuroendocrine alternations and its lateralization in adolescents with major depressive disorder.BMC psychiatry · 2024Article
- Stress and Epilepsy: Towards Understanding of Neurobiological Mechanisms for Better Management.eNeuro · 2023Review
- Prevalence of depression in junior and senior adolescents.Frontiers in psychiatry · 2023Article
- Rethinking the risk for depression using the RDoC: A psychophysiological perspective.Frontiers in psychology · 2023Review
- The gut microbiota, HPA axis, and brain in adolescent-onset depression: Probiotics as a novel treatment.Brain, behavior, & immunity - health · 2022Article
- In(s) and out(s) of adolescent depression - Trajectories of development and recovery.Brain, behavior, & immunity - health · 2021Article
- Altered markers of stress in depressed adolescents after acute social media use.Journal of psychiatric research · 2021Article
- Dynamics and determinants of cortisol and alpha-amylase responses to repeated stressors in recent interpersonal trauma survivors.Psychoneuroendocrinology · 2020Article
- Early life stress, cortisol, frontolimbic connectivity, and depressive symptoms during puberty.Development and psychopathology · 2019Article
- Cognitive reappraisal attenuates the association between depressive symptoms and emotional response to stress during adolescence.Cognition & emotion · 2019Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAltered hypothalamic-pituitary-adrenal (HPA) function is common in youth with major depressive disorder (MDD) but variability in the strength and direction of HPA alterations has prompted a search for symptom-based subtypes with unique neuroendocrine signatures. This study investigated the extent to which depressive symptom composites were differentially associated with cortisol responses to psychosocial stress.
methodsThis study examined salivary cortisol responses to the Trier Social Stress Test (TSST) in 145 adolescents who varied in their risk for MDD: 38 had current MDD; 35 were healthy but at high risk for MDD based on having one or both parents with unipolar MDD; and 72 were healthy youth with no personal or family history of a psychiatric disorder. Multilevel models examined within-person change in cortisol levels during a 2-h resting phase prior to the TSST and both linear and quadratic changes in cortisol levels following the TSST.
resultsAnticipatory cortisol reactivity was lower in MDD youth compared to low-risk youth, and in youth with higher compared to lower depressive symptom severity. Whereas affective symptoms were associated with increased anticipatory cortisol reactivity and more rapid recovery to the TSST, neurovegetative symptoms were associated with decreased anticipatory cortisol reactivity and slower recovery. LIMITATIONS: The cross-sectional design does not permit inferences regarding temporal relations between cortisol responses and depressive symptom composites.
conclusionsThe present findings suggest that heterogeneity among studies examining HPA reactivity in depressed youth may be driven, in part, by differences in depressive symptom composites across samples.
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Registered trials
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