Observational studyPloS one2017
Relationship between Hemoglobin Levels Corrected by Interdialytic Weight Gain and Mortality in Japanese Hemodialysis Patients: Miyazaki Dialysis Cohort Study.
Observational study in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Executive summary of the Korean Society of Nephrology 2021 clinical practice guideline for optimal hemodialysis treatment.The Korean journal of internal medicine · 2022Guideline
- Korean Society of Nephrology 2021 Clinical Practice Guideline for Optimal Hemodialysis Treatment.Kidney research and clinical practice · 2021Guideline
- A pharmacist-managed dosing algorithm for darbepoetin alfa and iron sucrose in hemodialysis patients: A randomized, controlled trial.Pharmacology research & perspectives · 2020Trial
- Differences in circulatory dynamics and skeletal muscle blood flow during exercise between post-dialysis and non-dialysis days in hemodialysis patients.International urology and nephrology · 2026Article
- Usage of the Anemia Control Model Is Associated with Reduced Hospitalization Risk in Hemodialysis.Biomedicines · 2024Article
- Risk factors for short-term all-cause mortality in patients with end stage renal disease: a scoping review.BMC nephrology · 2024Article
- Predictive role of cardiac valvular calcification in all-cause mortality of Chinese initial haemodialysis patients: a follow-up study of 4 years.BMC nephrology · 2023Article
- Executive Summary of the Korean Society of Nephrology 2021 Clinical Practice Guideline for Optimal Hemodialysis Treatment.Kidney research and clinical practice · 2021Article
- Erratum: Interdialytic Weight Gain Effects on Hemoglobin Concentration and Cardiovascular Events.Kidney international reports · 2021Article
- Interdialytic Weight Gain Effects on Hemoglobin Concentration and Cardiovascular Events.Kidney international reports · 2020Article
- The Impact of CKD Anaemia on Patients: Incidence, Risk Factors, and Clinical Outcomes-A Systematic Literature Review.International journal of nephrology · 2020Article
- Epoetin alfa resistance in hemodialysis patients with chronic kidney disease: a longitudinal study.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough hemoglobin (Hb) levels are affected by a change in the body fluid status, the relationship between Hb levels and mortality while taking interdialytic weight gain (IDWG) at blood sampling into account has not yet been examined in hemodialysis patients. STUDY
designCohort study. SETTING,
participantsData from the Miyazaki Dialysis cohort study, including 1375 prevalent hemodialysis patients (median age (interquartile range), 69 (60-77) years, 42.3% female). PREDICTOR: Patients were divided into 5 categories according to baseline Hb levels and two groups based on the median value of IDWG rates at blood sampling at pre-HD on the first dialysis session of the week. OUTCOMES: All-cause and cardiovascular mortalities during a 3-year follow-up. MEASUREMENTS: Hazard ratios were estimated using a Cox model for the relationship between Hb categories and mortality, and adjusted for potential confounders such as age, sex, dialysis duration, erythropoiesis-stimulating agent dosage, Kt/V, comorbid conditions, anti-hypertensive drug use, serum albumin, serum C-reactive protein, serum ferritin, and serum intact parathyroid hormone. Patients with Hb levels of 9-9.9 g/dL were set as our reference category.
resultsA total of 246 patients (18%) died of all-cause mortality, including 112 cardiovascular deaths. Lower Hb levels (<9.0g/dL) were associated with all-cause mortality (adjusted HRs 2.043 [95% CI, 1.347-3.009]), while Hb levels were not associated with cardiovascular mortality. When patients were divided into two groups using the median value of IDWG rates (high IDWG, ≥5.4% and low IDWG, <5.4%), the correlation between lower Hb levels and all-cause mortality disappeared in high IDWG patients, but was maintained in low IDWG patients (adjusted HRs 3.058 [95% CI,1.575-5.934]). On the other hand, higher Hb levels (≥12g/dL) were associated with cardiovascular mortality in high IDWG patients (adjusted HRs 2.724 [95% CI, 1.010-7.349]), but not in low IDWG patients.
conclusionIn hemodialysis patients, target Hb levels may need to be selected in consideration of IDWG at blood sampling.
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