ArticlePloS one2017
Human and Mouse Hematopoietic Stem Cells Are a Depot for Dormant Mycobacterium tuberculosis.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Host-pathogen interactions in tuberculosis: from immunological mechanisms to translational applications.Cell insight · 2026Review
- Mycobacterium tuberculosis infects human peripheral hematopoietic multipotent progenitors and promotes their myeloid differentiation in vitro.Cell death & disease · 2026Article
- Development of a score derived from full blood count parameters to differentiate individuals with tuberculosis disease from those with tuberculosis infection.Clinical and experimental immunology · 2026Article
- Mycobacterium tuberculosis growth inhibition by peripheral blood mononuclear cells from household contacts is not affected by previous SARS-CoV-2 infection.Gates open research · 2025Article
- Article
- Detection ofThe European respiratory journal · 2024Article
- Detection of Mycobacterial DNA in Human Bone Marrow.Microorganisms · 2023Article
- Serum amyloid A proteins reduce bone mass during mycobacterial infections.Frontiers in immunology · 2023Article
- Infection with hypervirulentFrontiers in immunology · 2023Article
- Tuberculosis Infection in Children and Adolescents.Pathogens (Basel, Switzerland) · 2022Review
- Long-term hematopoietic stem cells as a parasite niche during treatment failure in visceral leishmaniasis.Communications biology · 2022Article
- Dormancy: There and Back Again.Molecular biology · 2022Article
- Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition).European journal of immunology · 2021Review
- The definition of tuberculosis infection based on the spectrum of tuberculosis disease.Breathe (Sheffield, England) · 2021Review
- Redox homeostasis in Mycobacterium tuberculosis is modulated by a novel actinomycete-specific transcription factor.The EMBO journal · 2021Article
- Detection ofThe Lancet. Microbe · 2021Observational
- Monocyte progenitors give rise to multinucleated giant cells.Nature communications · 2021Article
- Review
- The knowns and unknowns of latent Mycobacterium tuberculosis infection.The Journal of clinical investigation · 2021Review
- Ex vivo mRNA expression of toll-like receptors during latent tuberculosis infection.BMC immunology · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An estimated third of the world's population is latently infected with Mycobacterium tuberculosis (Mtb), with no clinical signs of tuberculosis (TB), but lifelong risk of reactivation to active disease. The niches of persisting bacteria during latent TB infection remain unclear. We detect Mtb DNA in peripheral blood selectively in long-term repopulating pluripotent hematopoietic stem cells (LT-pHSCs) as well as in mesenchymal stem cells from latently infected human donors. In mice infected with low numbers of Mtb, that do not develop active disease we, again, find LT-pHSCs selectively infected with Mtb. In human and mouse LT-pHSCs Mtb are stressed or dormant, non-replicating bacteria. Intratracheal injection of Mtb-infected human and mouse LT-pHSCs into immune-deficient mice resuscitates Mtb to replicating bacteria within the lung, accompanied by signs of active infection. We conclude that LT-pHSCs, together with MSCs of Mtb-infected humans and mice serve as a hitherto unappreciated quiescent cellular depot for Mtb during latent TB infection.
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