ArticlePloS one2017
Development of the Liverpool Adverse Drug Reaction Avoidability Assessment Tool.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Risk prediction models for adverse drug reactions and adverse drug events in older adults-a systematic review and meta-analysis.European journal of clinical pharmacology · 2025Pooled it
- Dacomitinib-Induced Paronychia Associated With PRIDE Syndrome in a Patient With Non-Small Cell Lung Cancer.Cureus · 2025Article
- Heparin-Induced Hyperkalemia Assessment Utilizing the Naranjo Adverse Drug Reaction Probability Scale: A 40-Year Systematic Review.Pharmacy (Basel, Switzerland) · 2025Review
- Assessment of severity and avoidability of adverse drug reactions in neonates: a reproducibility study of the Hartwig tool and LAAT.European journal of clinical pharmacology · 2025Observational
- Patients' Identification, Management and Prevention of Adverse Drug Reactions: A Cross-Sectional Survey of Patients with Severe Adverse Drug Reactions.Journal of clinical medicine · 2024Article
- Adverse drug reactions, multimorbidity and polypharmacy: a prospective analysis of 1 month of medical admissions.BMJ open · 2022Observational
- Safety of Antibiotics in Hospitalized Children in Romania: A Prospective Observational Study.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Article
- Causality and avoidability of adverse drug reactions of antibiotics in hospitalized children: a cohort study.International journal of clinical pharmacy · 2021Article
- An investigation into the avoidability of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome.Scientific reports · 2021Article
- Translation, transcultural adaptation and validation to Brazilian Portuguese of tools for adverse drug reaction assessment in children.BMC medical research methodology · 2021Article
- Comment: Drug-Induced Liver Injury (DILI) With Micafungin: The Importance of Causality Assessment.The Annals of pharmacotherapy · 2021Article
- Adverse Drug Reactions Spontaneously Reported at a Tertiary Care Hospital and Preventable Measures Implemented.Journal of clinical pharmacy and therapeutics · 2021Article
- Avoidability of drug-induced liver injury (DILI) in an elderly hospital cohort with cases assessed for causality by the updated RUCAM score.BMC geriatrics · 2020Article
- An investigation into the avoidability of adverse drug reactions using the LAAT and modified Hallas tools.Medicine · 2020Observational
- Post marketing surveillance of suspected adverse drug reactions through spontaneous reporting: current status, challenges and the future.Therapeutic advances in drug safety · 2020Review
- Adverse Drug Reactions in Norway: A Systematic Review.Pharmacy (Basel, Switzerland) · 2019Review
- Article
- A Pathway to Healthier Aging or an Illusion? A Narrative Review on Deprescribing Protocols for the Elderly.Sage open agingReview
- Reactions related to asparaginase infusion in a 10-year retrospective cohort.Revista brasileira de hematologia e hemoterapiaArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
aimTo develop and test a new tool to assess the avoidability of adverse drug reactions that is suitable for use in paediatrics but which is also applicable to a variety of other settings.
methodsThe study involved multiple phases. Preliminary work involved using the Hallas scale and a modification of the existing Hallas scale, to assess two different sets of adverse drug reaction (ADR) case reports. Phase 1 defined, modified and refined a new tool using multidisciplinary teams. Phase 2 involved the assessment of 50 ADR case reports from a prospective study of paediatric inpatients by individual assessors. Phase 3 compared assessments with the new tool for individuals and groups in comparison to the 'gold standard' (the avoidability outcome set by a panel of senior investigators: an experienced clinical pharmacologist, paediatrician and pharmacist).
main outcome measuresInter-rater reliability (IRR), measure of disagreement and utilization of avoidability categories.
resultsPreliminary work-Pilot phase: results for the original Hallas cases were fair and pairwise kappa scores ranged from 0.21 to 0.36. Results for the modified Hallas cases were poor, pairwise kappa scores ranged from 0.06 to 0.16. Phase 1: on initial use of the new tool, agreement between the two multidisciplinary groups was found on 13/20 cases with a kappa score of 0.29 (95% CI -0.04 to 0.62). Phase 2: the assessment of 50 ADR case reports by six individual reviewers yielded pairwise kappa scores ranging from poor to good 0.12 to 0.75 and percentage exact agreement (%EA) ranged from 52-90%. Phase 3: Percentage exact agreement ranged from 35-70%. Overall, individuals had better agreement with the 'gold standard'.
conclusionAvoidability assessment is feasible but needs careful attention to methods. The Liverpool ADR avoidability assessment tool showed mixed IRR. We have developed and validated a method for assessing the avoidability of ADRs that is transparent, more objective than previous methods and that can be used by individuals or groups.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.