ArticlePloS one2017
Analysis of Hypoxic and Hypercapnic Ventilatory Response in Healthy Volunteers.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- The normal distribution of the hypoxic ventilatory response and methodological impacts: a meta-analysis and computational investigation.The Journal of physiology · 2023Pooled it
- Sex differences in loop gain measured via superimposed end-expiratory breath holds and inspired steady-state hypoxia.Experimental physiology · 2026Article
- Roles of peripheral and central µAmerican journal of physiology. Lung cellular and molecular physiology · 2025Article
- Sex-differences in Mountain Ultra-trail Performance: Look at the Scenery.Sports medicine - open · 2025Article
- Article
- Using modified Fenn diagrams to assess ventilatory acclimatization during ascent to high altitude: Effect of acetazolamide.Experimental physiology · 2024Article
- Women at Altitude: Sex-Related Physiological Responses to Exercise in Hypoxia.Sports medicine (Auckland, N.Z.) · 2024Review
- The impact of hormones on lung development and function: an overlooked aspect to consider from early childhood.Frontiers in endocrinology · 2024Review
- Multivariate time-series sensor vital sign forecasting of cardiovascular and chronic respiratory diseases.Sustainable computing : informatics and systems · 2023Article
- Hypoxia modeling techniques: A review.Heliyon · 2023Review
- Maximal pulmonary ventilation and lactate affect the anaerobic performance in young women exposed to hypobaric hypoxia.Frontiers in physiology · 2023Article
- High-flow nasal cannula therapy, factors affecting effective inspired oxygen fraction: an experimental adult bench model.Journal of clinical monitoring and computing · 2022Article
- Primum non nocere; It's time to consider altitude training as the medical intervention it actually is!Frontiers in psychology · 2022Review
- The ventilatory response to hypoxia is blunted in some preterm infants during the second year of life.Frontiers in pediatrics · 2022Article
- Postexercise urinary alpha-1 acid glycoprotein is not dependent on hypoxia.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Sex and gender in respiratory physiology.European respiratory review : an official journal of the European Respiratory Society · 2021Article
- Cardiorespiratory Coordination in Hypercapnic Test Before and After High-Altitude Expedition.Frontiers in physiology · 2021Article
- A Machine-Learning-Based System for Prediction of Cardiovascular and Chronic Respiratory Diseases.Journal of healthcare engineering · 2021Article
- Percutaneous Closure of PFO in Patients with Reduced Oxygen Saturation at Rest and during Exercise: Short- and Long-Term Results.Journal of interventional cardiology · 2020Article
- Carotid Bodies and the Integrated Cardiorespiratory Response to Hypoxia.Physiology (Bethesda, Md.) · 2018Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
Abstract
introductionA previous study has suggested that the Human Leukocyte Antigen (HLA) allele DQB1*06:02 affects hypoxic ventilatory response (HVR) but not hypercapnic ventilatory response (HCVR) in an Asian population. The current study evaluated the relationship in Caucasians and Asians. In addition we assessed whether gender or polymorphisms in genes participating in the control of breathing affect HVR and HCVR.
methodsA re-breathing system was used to measure HVR and HCVR in 551 young adults (56.8% Caucasians, 30% Asians). HLA-DQB1*06:02 and tagged polymorphisms and coding variants in genes participating in breathing (PHOX2B, GPR4 and TASK2/KCNK5) were analyzed. The associations between HVR/HCVR and HLA-DQB1*06:02, genetic polymorphisms, and gender were evaluated using ANOVA or frequentist association testing with SNPTEST.
resultsHVR and gender are strongly correlated. HCVR and gender are not. Mean HVR in women was 0.276±0.168 (liter/minute/%SpO2) compared to 0.429±0.266 (liter/minute/%SpO2) in men, p<0.001 (55.4% higher HVR in men). Women had lower baseline minute ventilation (8.08±2.36 l/m vs. 10.00±3.43l/m, p<0.001), higher SpO2 (98.0±1.3% vs. 96.6±1.7%, p<0.001), and lower EtCO2 (4.65±0.68% vs. 4.82±1.02%, p = 0.025). One hundred and two (18.5%) of the participants had HLA-DQB1*06:02. No association was seen between HLA-DQB1*06:02 and HVR or HCVR. Genetic analysis revealed point wise, uncorrected significant associations between two TASK2/KCNK5 variants (rs2815118 and rs150380866) and HCVR.
conclusionsThis is the largest study to date reporting the relationship between gender and HVR/ HCVR and the first study assessing the association between genetic polymorphisms in humans and HVR/HCVR. The data suggest that gender has a large effect on hypoxic breathing response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.