Evidence map›Paper›PMID 28045993›Full record

ArticlePloS one2017

Change in the Interstitial Cells of Cajal and nNOS Positive Neuronal Cells with Aging in the Stomach of F344 Rats.

Yong Hwan Kwon, Nayoung Kim, Ryoung Hee Nam, Ji Hyun Park, Sun Min Lee, Sung Kook Kim, Hye Seung Lee, Yong Sung Kim, Dong Ho Lee

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Experimental and therapeutic medicine · 2021
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  3. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Yong Hwan KwonDepartments of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Nayoung KimDepartments of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Ryoung Hee NamDepartments of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Ji Hyun ParkDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Sun Min LeeDepartments of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Sung Kook KimDepartment of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.
Hye Seung LeeDepartments of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea.
Yong Sung KimDepartment of Gastroenterology and Digestive Disease Research Institute, Wonkwang University School of Medicine, Iksan, Korea.
Dong Ho LeeDepartments of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Seoul National University Bundang Hospital · KRKyungpook National University Hospital · KRSeoul National University · KRWonkwang University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gastric accommodation reflex is an important mechanism in gastric physiology. However, the aging-associated structural and functional changes in gastric relaxation have not yet been established. Thus, we evaluated the molecular changes of interstitial cell of Cajal (ICC) and neuronal nitric oxide synthase (nNOS) and the function changes in the corpus of F344 rats at different ages (6-, 31-, 74-wk and 2-yr). The proportion of the c-Kit-positive area in the submucosal border (SMB) and myenteric plexus (MP) layer was significantly lower in the older rats, as indicated by immunohistochemistry. The density of the nNOS-positive immunoreactive area also decreased with age in the SMB, circular muscle (CM), and MP. Similarly, the percent of nNOS-positive neuronal cells per total neuronal cells and the proportion of nNOS immunoreactive area of MP also decreased in aged rats. In addition, the mRNA and protein expression of c-Kit and nNOS significantly decreased with age. Expression of stem cell factor (SCF) and the pan-neuronal marker PGP 9.5 mRNA was significantly lower in the older rats than in the younger rats. Barostat studies showed no difference depending on age. Instead, the change of volume was significantly decreased by L-NG63-nitroarginine methyl ester in the 2-yr-old rats compared with the 6-wk-old rats (P = 0.003). Taken together, the quantitative and molecular nNOS changes in the stomach might play a role in the decrease of gastric accommodation with age.

Indexed as

AgingAnimalsEnteric Nervous SystemImmunohistochemistryInterstitial Cells of CajalMaleMyenteric PlexusNeuronsNG-Nitroarginine Methyl EsterNitric Oxide Synthase Type IProto-Oncogene Proteins c-kitRatsRats, Inbred F344RNA, MessengerStem Cell FactorStomachNG-Nitroarginine Methyl EsterNitric Oxide Synthase Type INos1 protein, ratProto-Oncogene Proteins c-kitRNA, MessengerStem Cell Factor

Identifiers

PMID28045993
PMCPMC5207530
OpenAlexW2571143037

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.