ArticlePloS one2017
The BACHD Rat Model of Huntington Disease Shows Signs of Fronto-Striatal Dysfunction in Two Operant Conditioning Tests of Short-Term Memory.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Introducing a Computerized Figural Memory Test Based on Automatic Item Generation: An Analysis With the Rasch Poisson Counts Model.Frontiers in psychology · 2020Article
- Motivational Impairment is Accompanied by Corticoaccumbal Dysfunction in the BACHD-Tg5 Rat Model of Huntington's Disease.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Modern approaches for modelling dystonia and Huntington's disease in vitro and in vivo.International journal of experimental pathology · 2019Review
- Response inhibition and fronto-striatal-thalamic circuit dysfunction in cocaine addiction.Drug and alcohol dependence · 2018Article
- Article
- The Alteration of Emotion Regulation Precedes the Deficits in Interval Timing in the BACHD Rat Model for Huntington Disease.Frontiers in integrative neuroscience · 2018Article
- BACHD rats expressing full-length mutant huntingtin exhibit differences in social behavior compared to wild-type littermates.PloS one · 2018Article
- The BACHD Rat Model of Huntington Disease Shows Specific Deficits in a Test Battery of Motor Function.Frontiers in behavioral neuroscience · 2017Article
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4 authors.
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Abstract
The BACHD rat is a recently developed transgenic animal model of Huntington disease, a progressive neurodegenerative disorder characterized by extensive loss of striatal neurons. Cognitive impairments are common among patients, and characterization of similar deficits in animal models of the disease is therefore of interest. The present study assessed the BACHD rats' performance in the delayed alternation and the delayed non-matching to position test, two Skinner box-based tests of short-term memory function. The transgenic rats showed impaired performance in both tests, indicating general problems with handling basic aspects of the tests, while short-term memory appeared to be intact. Similar phenotypes have been found in rats with fronto-striatal lesions, suggesting that Huntington disease-related neuropathology might be present in the BACHD rats. Further analyses indicated that the performance deficit in the delayed alternation test might be due to impaired inhibitory control, which has also been implicated in Huntington disease patients. The study ultimately suggests that the BACHD rats might suffer from neuropathology and cognitive impairments reminiscent of those of Huntington disease patients.
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