ArticlePloS one2017
Critical Size Bone Defect Healing Using Collagen-Calcium Phosphate Bone Graft Materials.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Article
- Bone regeneration induced by a novel quercetin/a-CSH/n-HA composite in critical size tibia defect of rats with osteoporosis.Scientific reports · 2025Article
- Bone regeneration using moldable calcium phosphate with and without recombinant human BMP-2 in a rabbit critical-sized metaphyseal core defect model.Journal of orthopaedic surgery and research · 2025Article
- Universal Hydrogel Carrier Enhances Bone Graft Success: Preclinical and Clinical Evaluation.Advanced healthcare materials · 2025Article
- Functionalization of collagen fiber with nano-islands of silver via atomic layer deposition to promote bone healing.Heliyon · 2025Article
- Article
- Decellularized Antler Cancellous Bone Matrix Material Can Serve as Potential Bone Tissue Scaffold.Biomolecules · 2024Article
- Bioactive ceramic-based materials: beneficial properties and potential applications in dental repair and regeneration.Regenerative medicine · 2024Review
- A Comparative Study of HA/DBM Compounds Derived from Bovine and Porcine for Bone Regeneration.Journal of functional biomaterials · 2023Article
- Evaluation of decellularization process for developing osteogenic bovine cancellous bone scaffolds in-vitro.PloS one · 2023Article
- Effect of ascorbic acid and epidermal growth factor in a rat tibia defect.Acta cirurgica brasileira · 2023Article
- Regenerative Efficacy of Supercritical Carbon Dioxide-Derived Bone Graft Putty in Rabbit Bone Defect Model.Biomedicines · 2022Article
- Beyond the pedicle screw-a patent review.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022Review
- A Mini-Pig Mandibular Defect Model for Evaluation of Craniomaxillofacial Bone Regeneration.Tissue engineering. Part C, Methods · 2022Article
- A Comparative Study of Two Bone Graft Substitutes-InterOssJournal of functional biomaterials · 2022Article
- Biologically modified implantation as therapeutic bioabsorbable materials for bone defect repair.Regenerative therapy · 2022Review
- Repair of bone defects in rhesus monkeys with α1,3-galactosyltransferase-knockout pig cancellous bone.Frontiers in bioengineering and biotechnology · 2022Article
- Temporal response of an injectable calcium phosphate material in a critical size defect.Journal of orthopaedic surgery and research · 2021Article
- Comparative osteoconductivity of bone void fillers with antibiotics in a critical size bone defect model.Journal of materials science. Materials in medicine · 2020Article
- MagnetOs, Vitoss, and Novabone in a Multi-endpoint Study of Posterolateral Fusion: A True Fusion or Not?Clinical spine surgery · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The need for bone graft materials to fill bony voids or gaps that are not related to the intrinsic stability of the bone that arise due to trauma, tumors or osteolysis remains a clinically relevant and significant issue. The in vivo response of collagen-tricalcium phosphate bone graft substitutes was evaluated in a critical size cancellous defect model in skeletally mature rabbits. While the materials were chemically virtually identical, new bone formation, implant resorption and local in vivo responses were significantly different. Differences in the in vivo response may be due, in part, collagen source and processing which influences resorption profiles. Continued improvements in processing and manufacturing techniques of collagen-tricalcium phosphate bone graft substitutes can result in osteoconductive materials that support healing of critical size bone defects even in challenging pre-clinical models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.