ArticlePloS one2017
Alkalosis in Critically Ill Patients with Severe Sepsis and Septic Shock.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Severe alkalemia in the emergency department : Acid-base patterns, clinical presentation and short-term outcomes in hospitalized patients.Wiener klinische Wochenschrift · 2026Article
- The prognostic significance of the mechanism of mild to moderate alkalemia at emergency department admission.BMC emergency medicine · 2026Article
- Impact of base excess on mortality in patients with sepsis-associated acute kidney injury: insights from US Intensive Care Unit Cohort.International urology and nephrology · 2026Article
- Integrated Electrochemical Aptamer Biosensing and Colorimetric pH Monitoring via Hydrogel Microneedle Assays for Assessing Antibiotic Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The Effect of Extreme Alkalemia upon Presentation to the Emergency Department on Patient Outcomes.Journal of clinical medicine · 2024Article
- Metabolic alkalosis: a new red flag in status epilepticus.Journal of neurology · 2024Observational
- Machine Learning for Predicting Risk and Prognosis of Acute Kidney Disease in Critically Ill Elderly Patients During Hospitalization: Internet-Based and Interpretable Model Study.Journal of medical Internet research · 2024Article
- Lactic alkalosis in intensive care: a red flag?Critical care (London, England) · 2023Article
- Association between base excess and 28-day mortality in sepsis patients: A secondary analysis based on the MIMIC- IV database.Heliyon · 2023Article
- Validating the APACHE IV score in predicting length of stay in the intensive care unit among patients with sepsis.Scientific reports · 2023Article
- Identifying and analyzing sepsis states: A retrospective study on patients with sepsis in ICUs.PLOS digital health · 2022Article
- In situ monitoring reveals cellular environmental instabilities in human pluripotent stem cell culture.Communications biology · 2022Article
- The frequency of acid-base disorders on admission to the intensive care and its association with in-hospital outcome, Cape Town, South Africa: a retrospective cohort study.The Pan African medical journal · 2022Article
- COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches.GeroScience · 2020Review
- ACE/ACE2 Ratio: A Key Also in 2019 Coronavirus Disease (Covid-19)?Frontiers in medicine · 2020Article
- Correction: Alkalosis in Critically Ill Patients with Severe Sepsis and Septic Shock.PloS one · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAlthough metabolic alkalosis is a common occurrence in intensive care units (ICUs), no study has evaluated its prevalence or outcomes in patients with severe sepsis or septic shock.
methodsThis is a retrospective cohort study of critically ill patients suffering from severe sepsis and septic shock admitted to the ICUs of Halmstad and Varberg County hospitals. From 910 patient records, 627 patients met the inclusion criteria. We investigated the relationship between metabolic alkalosis and mortality. Further, we studied the relationship between metabolic alkalosis and ICU length of stay (LOS).
resultsMetabolic alkalosis was associated with decreased 30-day and 12-month mortalities. This effect was however lost when a multivariate analysis was conducted, correcting for age, gender, pH on admission, base excess (BE) on admission, Simplified Acute Physiology Score III (SAPS III) and acute kidney injury (AKI). We then analyzed for any dose-response effect between the severity of metabolic alkalosis and mortality and found no relationship. Bivariate analysis showed that metabolic alkalosis had a significant effect on the length of ICU stay. When adjusting for age, sex, pH at admission, BE at admission, SAPS III and AKI in a multivariate analysis, metabolic alkalosis significantly contributed to prolonged ICU length of stay. In two separate sensitivity analyses pure metabolic alkalosis and late metabolic alkalosis (time of onset >48 hours) were the only significant predictor of increased ICU length of stay.
conclusionMetabolic alkalosis did not have any effect on 30-day and 12-month mortalities after adjusting for age, sex, SAPS III-score, pH and BE on admission and AKI in a multivariate analysis. The presence of metabolic alkalosis was independently associated with an increased ICU length of stay.
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