Evidence map›Paper›PMID 28045584›Full record

ReviewNucleus (Austin, Tex.)2017

Epigenetic countermarks in mitotic chromosome condensation.

Karel H M van Wely, Carmen Mora Gallardo, Kendra R Vann, Tatiana G Kutateladze

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nucleus (Austin, Tex.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Mitotic chromosomes.Seminars in cell & developmental biology · 2021
    Review
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Karel H M van Welya Department of Immunology and Oncology , Centro Nacional de Biotecnología/CSIC , Madrid , Spain.
Carmen Mora Gallardoa Department of Immunology and Oncology , Centro Nacional de Biotecnología/CSIC , Madrid , Spain.
Kendra R Vannb Department of Pharmacology , University of Colorado School of Medicine , Aurora , CO , USA.
Tatiana G Kutateladzeb Department of Pharmacology , University of Colorado School of Medicine , Aurora , CO , USA.

Funding

Epigenetic regulation by PHF1R01GM106416 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2015 to 2018
$1.5M
Molecular mechanism of chromatin targeting by BRPF1R01GM100907 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2015 to 2018
$1.4M
NIGMS NIH HHS R01 GM100907NIGMS NIH HHS R01 GM106416
6 · The paper itself

Abstract

Mitosis in metazoans is characterized by abundant phosphorylation of histone H3 and involves the recruitment of condensin complexes to chromatin. The relationship between the 2 phenomena and their respective contributions to chromosome condensation in vivo remain poorly understood. Recent studies have shown that H3T3 phosphorylation decreases binding of histone readers to methylated H3K4 in vitro and is essential to displace the corresponding proteins from mitotic chromatin in vivo. Together with previous observations, these data provide further evidence for a role of mitotic histone H3 phosphorylation in blocking transcriptional programs or preserving the 'memory' PTMs. Mitotic protein exclusion can also have a role in depopulating the chromatin template for subsequent condensin loading. H3 phosphorylation thus serves as an integral step in the condensation of chromosome arms.

Indexed as

Epigenesis, GeneticChromatinChromosome SegregationHumansMitosisChromatinAurora Bchromatin condensationepigeneticsHaspinhistonehistone readermitosisphoshpo/methyl switch

Identifiers

PMID28045584
PMCPMC5403135

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.