ArticleChemical research in toxicology2017
Computational Model of Secondary Palate Fusion and Disruption.
Article in Chemical research in toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- A pipeline for developing AI-driven models to predict molecular initiating events: a case study on neural tube defects.Journal of cheminformatics · 2026Article
- Hypothesis-driven approach to developmental toxicity assessment: Using mechanistic information to inform testing.Reproductive toxicology (Elmsford, N.Y.) · 2026Review
- Loxl3 Affects Palatal Shelf Elevation by Regulating Cell Proliferation and Collagen Deposition.International journal of molecular sciences · 2025Article
- A computational dynamic systems model forCurrent research in toxicology · 2025Article
- Engineering a computable epiblast for in silico modeling of developmental toxicity.Reproductive toxicology (Elmsford, N.Y.) · 2024Article
- Design and mathematical analysis of activating transcriptional amplifiers that enable modular temporal control in synthetic juxtacrine circuits.Synthetic and systems biotechnology · 2023Article
- An improved multicellular human organoid model for the study of chemical effects on palatal fusion.Birth defects research · 2023Article
- Human-Based New Approach Methodologies in Developmental Toxicity Testing: A Step Ahead from the State of the Art with a Feto-Placental Organ-on-Chip Platform.International journal of environmental research and public health · 2022Review
- Parameterized Computational Framework for the Description and Design of Genetic Circuits of Morphogenesis Based on Contact-Dependent Signaling and Changes in Cell-Cell Adhesion.ACS synthetic biology · 2022Article
- Dose Addition in the Induction of Craniofacial Malformations in Zebrafish Embryos Exposed to a Complex Mixture of Food-Relevant Chemicals with Dissimilar Modes of Action.Environmental health perspectives · 2022Article
- Histological and Immunohistochemical Studies to Determine the Mechanism of Cleft Palate Induction after Palatal Fusion in Mice Exposed to TCDD.International journal of molecular sciences · 2022Article
- Computational model for fetal skeletal defects potentially linked to disruption of retinoic acid signaling.Frontiers in pharmacology · 2022Article
- Pluripotent stem cell assays: Modalities and applications for predictive developmental toxicity.Current research in toxicology · 2022Article
- FutureTox IV Workshop Summary: Predictive Toxicology for Healthy Children.Toxicological sciences : an official journal of the Society of Toxicology · 2021Review
- A Microphysiological Approach to Evaluate Effectors of Intercellular Hedgehog Signaling in Development.Frontiers in cell and developmental biology · 2021Article
- An ontology for developmental processes and toxicities of neural tube closure.Reproductive toxicology (Elmsford, N.Y.) · 2021Article
- Computational Biology andCurrent opinion in toxicology · 2020Article
- Meeting report on the NIDDK/AUA Workshop on Congenital Anomalies of External Genitalia: challenges and opportunities for translational research.Journal of pediatric urology · 2020Review
- Characterizing cleft palate toxicants using ToxCast data, chemical structure, and the biomedical literature.Birth defects research · 2020Article
- Synthetic development: building mammalian multicellular structures with artificial genetic programs.Current opinion in biotechnology · 2019Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Morphogenetic events are driven by cell-generated physical forces and complex cellular dynamics. To improve our capacity to predict developmental effects from chemical-induced cellular alterations, we built a multicellular agent-based model in CompuCell3D that recapitulates the cellular networks and collective cell behavior underlying growth and fusion of the mammalian secondary palate. The model incorporated multiple signaling pathways (TGFβ, BMP, FGF, EGF, and SHH) in a biological framework to recapitulate morphogenetic events from palatal outgrowth through midline fusion. It effectively simulated higher-level phenotypes (e.g., midline contact, medial edge seam (MES) breakdown, mesenchymal confluence, and fusion defects) in response to genetic or environmental perturbations. Perturbation analysis of various control features revealed model functionality with respect to cell signaling systems and feedback loops for growth and fusion, diverse individual cell behaviors and collective cellular behavior leading to physical contact and midline fusion, and quantitative analysis of the TGF/EGF switch that controls MES breakdown-a key event in morphogenetic fusion. The virtual palate model was then executed with theoretical chemical perturbation scenarios to simulate switch behavior leading to a disruption of fusion following chronic (e.g., dioxin) and acute (e.g., retinoic acid) chemical exposures. This computer model adds to similar systems models toward an integrative "virtual embryo" for simulation and quantitative prediction of adverse developmental outcomes following genetic perturbation and/or environmental disruption.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.