Evidence map›Paper›PMID 28045505›Full record

ArticleBiochemistry2017

Kemp Eliminase Activity of Ketosteroid Isomerase.

Vandana Lamba, Enis Sanchez, Lauren Rose Fanning, Kathryn Howe, Maria Alejandra Alvarez, Daniel Herschlag, Marcello Forconi

Abstract read
In one paragraph

Article in Biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. High throughput and quantitative enzymology in the genomic era.Current opinion in structural biology · 2021
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vandana LambaDepartment of Biochemistry, Stanford University , Stanford, California 94305, United States.
Enis SanchezDepartment of Chemistry and Biochemistry, College of Charleston , Charleston, South Carolina 29424, United States.
Lauren Rose FanningDepartment of Chemistry and Biochemistry, College of Charleston , Charleston, South Carolina 29424, United States.
Kathryn HowePalmetto Homeschool Association , Rock Hill, South Carolina 29730, United States.
Maria Alejandra AlvarezR. B. Stall High School , North Charleston, South Carolina 29418, United States.
Daniel HerschlagDepartment of Biochemistry, Stanford University , Stanford, California 94305, United States.
Marcello ForconiDepartment of Chemistry and Biochemistry, College of Charleston , Charleston, South Carolina 29424, United States.ORCID 0000-0002-5287-3757

Funding

South Carolina IDeA Networks of Biomedical Research (SC INBRE V)P20GM103499 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI EDIE C GOLDSMITH · 2012 to 2026
$61.0M
Supplement for South Carolina BRIN - 1P20 RR16461P20RR016461 · NCRR · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI DOOLEY, R. LARRY · 2001 to 2011
$32.3M
Howard Hughes Medical InstituteNCRR NIH HHS P20 RR016461NIGMS NIH HHS P20 GM103499
6 · The paper itself

Abstract

Kemp eliminases represent the most successful class of computationally designed enzymes, with rate accelerations of up to 10

Indexed as

ProtonsArginineAspartic AcidBacterial ProteinsBiocatalysisCloning, MolecularComamonas testosteroniEnzyme InhibitorsEscherichia coliGene ExpressionHydrophobic and Hydrophilic InteractionsIntramolecular LyasesKetosteroidsKineticsMolecular Docking SimulationMutationArginineAspartic AcidBacterial ProteinsEnzyme InhibitorsIntramolecular LyasesKetosteroidsOxazolesProtonsRecombinant ProteinsSteroid Isomerases

Identifiers

PMID28045505
PMCPMC5446047

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.