ReviewTranslational psychiatry2017
Neurogenetics of developmental dyslexia: from genes to behavior through brain neuroimaging and cognitive and sensorial mechanisms.
Review in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.
- Developmental dyslexia in children with perinatal exposure to hypoxia: A systematic review.PloS one · 2024Pooled it
- Associations between READ1 deletion, reading proficiency, and white matter network organisation in children with and without developmental dyslexia.Brain structure & function · 2026Article
- Kindergarten Screening for Early (Grade 1) and Late-Emerging (Grade 4) Dyslexia Risk.JAMA network open · 2026Article
- Multimodal data fusion in neuroscience: promises, challenges and future directions.IEEE signal processing magazine · 2025Article
- Mediational effects of reading-related intermediate phenotypes from polygenic scores to reading skills.NPJ science of learning · 2025Article
- Early developmental origins of cortical disorders modeled in human neural stem cells.Nature communications · 2025Article
- Linguistic and Cognitive Abilities in Children with Dyslexia: A Comparative Analysis.European journal of investigation in health, psychology and education · 2025Article
- Alterations in neural activation in the ventral frontoparietal network during complex magnocellular stimuli in developmental dyslexia associated with READ1 deletion.Behavioral and brain functions : BBF · 2024Article
- Action video games normalise the phonemic awareness in pre-readers at risk for developmental dyslexia.NPJ science of learning · 2024Article
- From brain to education through machine learning: Predicting literacy and numeracy skills from neuroimaging data.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Attention-deficit/hyperactive-impulsive disorder symptoms among grade 1 students with reading disorder in Thailand.Clinical and experimental pediatrics · 2023Article
- Article
- Associations between Dietary Intake, Blood Levels of Omega-3 and Omega-6 Fatty Acids and Reading Abilities in Children.Biomolecules · 2023Article
- Exploring Genetic and Neural Risk of Specific Reading Disability within a Nuclear Twin Family Case Study: A Translational Clinical Application.Journal of personalized medicine · 2023Article
- Developmental learning disorders in children with prenatal/perinatal exposure to hypoxia: A systematic review protocol.PloS one · 2023Article
- Sensory temporal sampling in time: an integrated model of the TSF and neural noise hypothesis as an etiological pathway for dyslexia.Frontiers in human neuroscience · 2023Review
- Patterns of Neural Functional Connectivity in Infants at Familial Risk of Developmental Dyslexia.JAMA network open · 2022Article
- The Functional Neuroanatomy of Reading Intervention.Frontiers in neuroscience · 2022Review
- Developmental Dyslexia: Environment Matters.Brain sciences · 2021Article
- The Polygenic Nature and Complex Genetic Architecture of Specific Learning Disorder.Brain sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Developmental dyslexia (DD) is a complex neurodevelopmental deficit characterized by impaired reading acquisition, in spite of adequate neurological and sensorial conditions, educational opportunities and normal intelligence. Despite the successful characterization of DD-susceptibility genes, we are far from understanding the molecular etiological pathways underlying the development of reading (dis)ability. By focusing mainly on clinical phenotypes, the molecular genetics approach has yielded mixed results. More optimally reduced measures of functioning, that is, intermediate phenotypes (IPs), represent a target for researching disease-associated genetic variants and for elucidating the underlying mechanisms. Imaging data provide a viable IP for complex neurobehavioral disorders and have been extensively used to investigate both morphological, structural and functional brain abnormalities in DD. Performing joint genetic and neuroimaging studies in humans is an emerging strategy to link DD-candidate genes to the brain structure and function. A limited number of studies has already pursued the imaging-genetics integration in DD. However, the results are still not sufficient to unravel the complexity of the reading circuit due to heterogeneous study design and data processing. Here, we propose an interdisciplinary, multilevel, imaging-genetic approach to disentangle the pathways from genes to behavior. As the presence of putative functional genetic variants has been provided and as genetic associations with specific cognitive/sensorial mechanisms have been reported, new hypothesis-driven imaging-genetic studies must gain momentum. This approach would lead to the optimization of diagnostic criteria and to the early identification of 'biologically at-risk' children, supporting the definition of adequate and well-timed prevention strategies and the implementation of novel, specific remediation approach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.