ArticleTranslational psychiatry2017
Neural substrates of cue reactivity and craving in gambling disorder.
Article in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
64 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Neural mechanisms of behavioral addiction: An ALE meta-analysis and MACM analysis.Journal of behavioral addictions · 2025Pooled it
- Craving in gambling disorder: A systematic review.Journal of behavioral addictions · 2023Pooled it
- Shared gray matter alterations in individuals with diverse behavioral addictions: A voxel-wise meta-analysis.Journal of behavioral addictions · 2020Pooled it
- Emotional Working Memory Training Treatment for Young Adult Problem Online Sports Bettors: A Preliminary Randomized Controlled Trial.Journal of gambling studies · 2024Trial
- A randomized double-blind sham-controlled preliminary study of a 5-week protocol of repetitive transcranial magnetic stimulation (rTMS) combined with cognitive behavioral therapy (CBT) for gambling disorder in Indonesia.Addictive behaviors reports · 2026Article
- Neural processing of win-contingent audiovisual cues during virtual gambling: an fMRI cross-over study.European archives of psychiatry and clinical neuroscience · 2026Article
- Sex Differences in Depression: Adult Cytogenesis as Potential Target for Precision Psychiatry.Cells · 2026Review
- Association between tobacco use, including heated tobacco products, and problem gambling: A cross-sectional study.Addictive behaviors reports · 2026Article
- Article
- Persistent appetitive memory in problematic pornography users.Journal of behavioral addictions · 2026Article
- Asymmetric Reinforcement Learning Explains Human Choice Patterns in Decision-making Under Risk.bioRxiv : the preprint server for biology · 2026Article
- Attentional biases in self-control are associated with reward cue-related brain activity.Social cognitive and affective neuroscience · 2026Article
- When cues take the wheel: cue-control across alcohol use disorder, binge-eating disorder, gambling disorder, and internet gaming disorder.Frontiers in psychology · 2026Review
- Addiction spectrum disorder: a conceptual framework for comprehensive understanding of addictive disorders.Frontiers in psychology · 2026Article
- A computational mechanism linking momentary craving and decision-making in alcohol drinkers and cannabis users.Nature. Mental health · 2026Article
- The role of craving in gambling behavior: examining its relevance and links to psychological distress, personality, and demographics.BMC psychology · 2025Article
- Sociocultural, Behavioral, and Physical Correlates of Excessive Social Media Use, Addiction, and Motivation Toward Reduction in a Hispanic College Student Sample.Journal of racial and ethnic health disparities · 2025Article
- Cue-Reactivity in Poker-Machine Gamblers: State Mindfulness and Cue-Reactive Urge to Gamble.Journal of gambling studies · 2025Article
- Associations Between Taq1A/C957T Polymorphic Variants and Autonomic Responsivity in a Slot Machine Task: Influence of Real-Life Gambling Exposure and Sex.Journal of gambling studies · 2025Article
- Striatal cue-reactivity and neurotransmitter function in gambling disorder.Journal of behavioral addictions · 2025Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Cue reactivity is an established procedure in addictions research for examining the subjective experience and neural basis of craving. This experiment sought to quantify cue-related brain responses in gambling disorder using personally tailored cues in conjunction with subjective craving, as well as a comparison with appetitive non-gambling stimuli. Participants with gambling disorder (n=19) attending treatment and 19 controls viewed personally tailored blocks of gambling-related cues, as well as neutral cues and highly appetitive (food) images during a functional magnetic resonance imaging (fMRI) scan performed ~2-3 h after a usual meal. fMRI analysis examined cue-related brain activity, cue-related changes in connectivity and associations with block-by-block craving ratings. Craving ratings in the participants with gambling disorder increased following gambling cues compared with non-gambling cues. fMRI analysis revealed group differences in left insula and anterior cingulate cortex, with the gambling disorder group showing greater reactivity to the gambling cues, but no differences to the food cues. In participants with gambling disorder, craving to gamble correlated positively with gambling cue-related activity in the bilateral insula and ventral striatum, and negatively with functional connectivity between the ventral striatum and the medial prefrontal cortex. Gambling cues, but not food cues, elicit increased brain responses in reward-related circuitry in individuals with gambling disorder (compared with controls), providing support for the incentive sensitization theory of addiction. Activity in the insula co-varied with craving intensity, and may be a target for interventions.
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