ArticleInternational journal of molecular sciences2017
Unraveling Massive Crocins Transport and Accumulation through Proteome and Microscopy Tools during the Development of Saffron Stigma.
Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 57 citations in OpenAlex.
- Research progress on differentiation and regulation of plant chromoplasts.Molecular biology reports · 2024Review
- Synthesis of Crocin I and Crocin II by Multigene Stacking inInternational journal of molecular sciences · 2023Article
- Dynamics of annatto pigment synthesis and accumulation in seeds of Bixa orellana L. revealed by integrated chemical, anatomical, and RNA-Seq analyses.Protoplasma · 2023Article
- Understanding saffron biology using omics- and bioinformatics tools: stepping towards a better Crocus phenome.Molecular biology reports · 2022Article
- Fortification and bioaccessibility of saffron apocarotenoids in potato tubers.Frontiers in nutrition · 2022Article
- Engineering high levels of saffron apocarotenoids in tomato.Horticulture research · 2022Article
- A New Glycosyltransferase Enzyme from Family 91, UGT91P3, Is Responsible for the Final Glucosylation Step of Crocins in Saffron (International journal of molecular sciences · 2021Article
- Flavescence Dorée-Derived Leaf Yellowing in Grapevine (Frontiers in plant science · 2020Article
- Prospects and progress on crocin biosynthetic pathway and metabolic engineering.Computational and structural biotechnology journal · 2020Review
- Multi-species transcriptome analyses for the regulation of crocins biosynthesis in Crocus.BMC genomics · 2019Article
- Transcript profiling of carotenoid/apocarotenoid biosynthesis genes during corm development of saffron (Crocus sativus L.).Protoplasma · 2019Article
- Article
- The Specialized Roles in Carotenogenesis and Apocarotenogenesis of the Phytoene Synthase Gene Family in Saffron.Frontiers in plant science · 2019Article
- Article
- Candidate Enzymes for Saffron Crocin Biosynthesis Are Localized in Multiple Cellular Compartments.Plant physiology · 2018Article
- Expression and Interaction Analysis among Saffron ALDHs and Crocetin Dialdehyde.International journal of molecular sciences · 2018Article
- Transcriptome analysis in tissue sectors with contrasting crocins accumulation provides novel insights into apocarotenoid biosynthesis and regulation during chromoplast biogenesis.Scientific reports · 2018Article
- Tissue-Specific Accumulation of Sulfur Compounds and Saponins in Different Parts of Garlic Cloves from Purple and White Ecotypes.Molecules (Basel, Switzerland) · 2017Article
- Molecular and biochemical characterization of a potato collection with contrasting tuber carotenoid content.PloS one · 2017Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crocins, the glucosides of crocetin, are present at high concentrations in saffron stigmas and accumulate in the vacuole. However, the biogenesis of the saffron chromoplast, the changes during the development of the stigma and the transport of crocins to the vacuole, are processes that remain poorly understood. We studied the process of chromoplast differentiation in saffron throughout stigma development by means of transmission electron microscopy. Our results provided an overview of a massive transport of crocins to the vacuole in the later developmental stages, when electron dense drops of a much greater size than plastoglobules (here defined "crocinoplast") were observed in the chromoplast, connected to the vacuole with a subsequent transfer of these large globules inside the vacuole. A proteome analysis of chromoplasts from saffron stigma allowed the identification of several well-known plastid proteins and new candidates involved in crocetin metabolism. Furthermore, expressions throughout five developmental stages of candidate genes responsible for carotenoid and apocarotenoid biogenesis, crocins transport to the vacuole and starch metabolism were analyzed. Correlation matrices and networks were exploited to identify a series of transcripts highly associated to crocetin (such as 1-Deoxy-d-xylulose 5-phosphate synthase (
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