ArticleScientific reports2017
Sex-related difference in human white matter volumes studied: Inspection of the corpus callosum and other white matter by VBM.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Sex differences in brain homotopic co-activations: a meta-analytic study.Brain structure & function · 2022Pooled it
- Dissecting the Strain and Sex Specific Connectome Signatures of Unanesthetized C57BL/6J and DBA/2J Mice Using Magnetic Resonance Imaging.Genes, brain, and behavior · 2026Article
- SliceMap: a binary classification-driven 2D pipeline for detecting discriminative candidate regions in brain MRI.Frontiers in neuroimaging · 2026Article
- Study of sex differences in the whole brain white matter using diffusion MRI tractography and suprathreshold fiber cluster statistics.NeuroImage. Clinical · 2026Article
- Article
- Study of Sex Differences in the Whole Brain White Matter Using Diffusion MRI Tractography and Suprathreshold Fiber Cluster Statistics.bioRxiv : the preprint server for biology · 2025Article
- Increased plasma GPNMB levels in patients with parkinson's disease and cognitive impairment.Scientific reports · 2025Article
- Sex Differences in Human Brain Structure at Birth.Biology of sex differences · 2024Article
- Prenatal polycyclic aromatic hydrocarbon exposure and neurodevelopment among children in Puerto Rico.Chemosphere · 2024Article
- Article
- Subcortical volume in middle-aged adults with fetal alcohol spectrum disorders.Brain communications · 2024Article
- Knockout of the orphan membrane transporter Slc22a23 leads to a lean and hyperactive phenotype with a small hippocampal volume.PloS one · 2024Article
- Is there hemispheric specialization in the chronic pain brain?Experimental neurology · 2022Review
- A Volumetric Study of the Corpus Callosum in the Turkish Population.Journal of neurological surgery. Part B, Skull base · 2022Article
- Sex and sensitive period differences in potential effects of maltreatment on axial versus radial diffusivity in the corpus callosum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Measuring Sex Differences in the Corpus Callosum by Undergraduates at a Small and a Large Institution.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2022Article
- The human dorsal hippocampal commissure: Delineating connections across the midline using multi-modal neuroimaging in major depressive disorder.Neuroimage. Reports · 2021Article
- Testing the extreme male brain hypothesis: Is autism spectrum disorder associated with a more male-typical brain?Autism research : official journal of the International Society for Autism Research · 2021Article
- Dynamic Functional Connectivity of EEG: From Identifying Fingerprints to Gender Differences to a General Blueprint for the Brain's Functional Organization.Frontiers in neuroscience · 2021Article
- Age-Related Variations in Regional White Matter Volumetry and Microstructure During the Post-adolescence Period: A Cross-Sectional Study of a Cohort of 1,713 University Students.Frontiers in systems neuroscience · 2021Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been contended that any observed difference of the corpus callosum (CC) size between men and women is not sex-related but brain-size-related. A recent report, however, showed that the midsagittal CC area was significantly larger in women in 37 brain-size-matched pairs of normal young adults. Since this constituted strong evidence of sexual dimorphism and was obtained from publicly available data in OASIS, we examined volume differences within the CC and in other white matter using voxel-based morphometry (VBM). We created a three-dimensional region of interest of the CC and measured its volume. The VBM statistics were analyzed by permutation test and threshold-free cluster enhancement (TFCE) with the significance levels at FWER < 0.05. The CC volume was significantly larger in women in the same 37 brain-size-matched pairs. We found that the CC genu was the subregion showing the most significant sex-related difference. We also found that white matter in the bilateral anterior frontal regions and the left lateral white matter near to Broca's area were larger in women, whereas there were no significant larger regions in men. Since we used brain-size-matched subjects, our results gave strong volumetric evidence of localized sexual dimorphism of white matter.
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