ArticleScientific reports2017
Effects of Elevated β-Estradiol Levels on the Functional Morphology of the Testis - New Insights.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 104 citations in OpenAlex.
- Cracking the fertility code: a comprehensive review of biomarkers and functional measures.Open biology · 2026Review
- Revisiting the dual role of androgens and oestrogens in mammalian sex differentiation with a focus on genitalia.Nature reviews. Urology · 2026Review
- Review
- Testis Molecular Pathways in CAIS Unveil Testosterone/Estradiol on Germ Cell Tumor Risk in Non-Obstructive Azoospermia.The Journal of clinical endocrinology and metabolism · 2026Article
- Plasma proteome adaptations during feminizing gender-affirming hormone therapy.Nature medicine · 2026Article
- Gender-affirming hormone therapy: Effect on semen quality and use of fertility preservation.Andrology · 2026Review
- Male Rat Model of Chemical Androgen Deprivation and Estrogenization from the Perspective of Anthropometric, Histological, and Biochemical Parameters.Medicina (Kaunas, Lithuania) · 2025Article
- Article
- First Diagnostic Questionnaire for Assessing Patients' Social Functioning: Comprehensive DDX3X Syndrome Patient Profile.Journal of clinical medicine · 2024Article
- Alliin Induces Reconstitution of Testes Damaged by Estrogen Overstimulation by Regulating Apoptosis.Current issues in molecular biology · 2024Article
- Clinical utility of serum 17-hydroxyprogesterone as a marker for medical therapy for male infertility: recommendations based on clinical scenarios.International journal of impotence research · 2023Review
- Gender-affirming hormonal therapy for transgender and gender-diverse people-A narrative review.Best practice & research. Clinical obstetrics & gynaecology · 2023Review
- Successful restoration of spermatogenesis following gender-affirming hormone therapy in transgender women.Cell reports. Medicine · 2023Article
- New perspectives on fertility in transwomen with regard to spermatogonial stem cells.Reproduction & fertility · 2023Review
- Steroid hormone signaling: multifaceted support of testicular function.Frontiers in cell and developmental biology · 2023Review
- Fertility counseling guide for transgender and gender diverse people.International journal of transgender health · 2023Article
- New metabolic signature for Chagas disease reveals sex steroid perturbation in humans and mice.Heliyon · 2022Article
- An Approach for Investigating Sexual Maturity in Wild Boar Males: Testosterone and 17β-Estradiol Analysis.Animals : an open access journal from MDPI · 2022Article
- Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment.Endocrine reviews · 2022Review
- Estrogenic Pastures: A Source of Endocrine Disruption in Sheep Reproduction.Frontiers in endocrinology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elevated estradiol levels are correlated with male infertility. Causes of hyperestrogenism include diseases of the adrenal cortex, testis or medications affecting the hypothalamus-pituitary-gonadal axis. The aim of our study was to elucidate the effects of estradiol treatment on testicular cellular morphology and function, with reference to the treatment regimen received. Testes samples (n = 9) were obtained post-orchiectomy from male-to-female transsexuals within the age range of 26-52 years. Each patient had a minimum of 1-6 years estradiol treatment. For comparison, additional samples were obtained from microscopically unaltered testicular tissue surrounding tumors (n = 7). The tissues obtained were investigated by stereomicroscopy, histochemistry, scanning electron microscopy (SEM) and immunohistochemistry. Our studies revealed that estradiol treatment significantly decreased the diameter of the seminiferous tubules (p < 0.05) and induced fatty degeneration in the surrounding connective tissue. An increase in collagen fiber synthesis in the extracellular matrix (ECM) surrounding the seminiferous tubules was also induced. Spermatogenesis was impaired resulting in mainly spermatogonia being present. Sertoli cells revealed diminished expression of estrogen receptor alpha (ERα). Both Sertoli and Leydig cells showed morphological alterations and glycoprotein accumulations. These results demonstrate that increased estradiol levels drastically impact the human testis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.