ArticleScientific reports2017
Diabetes, cardiac disorders and asthma as risk factors for severe organ involvement among adult dengue patients: A matched case-control study.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
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Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Dengue among immunocompromised patients: a systematic review and meta-analysis.Journal of travel medicine · 2025Pooled it
- Clinical signs and symptoms associated with WHO severe dengue classification: a systematic review and meta-analysis.Emerging microbes & infections · 2021Pooled it
- Different Associations betweenInternational journal of environmental research and public health · 2019Pooled it
- Assessing the burden of diabetes mellitus in dengue patients: A systematic review and meta-analysis.New microbes and new infections · 2026Article
- Epidemiological shift in age distribution of dengue in Thailand, 2005-2024.PLoS neglected tropical diseases · 2026Article
- Clinical and haematological correlates of severe dengue using 2023 epidemic data: A multicentre tertiary hospital-based analysis from Dhaka, Bangladesh.PLoS neglected tropical diseases · 2026Article
- Metabolic and cardiovascular comorbidities as predictors of severe dengue in Vietnamese adults: a retrospective study, 2022-2024.Osong public health and research perspectives · 2026Article
- Contribution of Immune Responses toJournal of inflammation research · 2026Article
- Dengue virus and lipid metabolism: unravelling the interplay for future therapeutic approaches.Emerging microbes & infections · 2025Review
- Epidemiology and severity risk factors of dengue virus infection during the 2023-2024 outbreak in Colombia.PLoS neglected tropical diseases · 2025Article
- Prognostic Indicators of Severe Dengue Infection in Adult Patients in Thailand.Tropical medicine and infectious disease · 2025Article
- Epidemiology of dengue fever in Somaliland: clinical features, and serological patterns from a retrospective study.BMC infectious diseases · 2025Article
- Association between severe headache or migraine and erectile dysfunction in American adults: a cross-sectional of data study from the NHANES.International journal of impotence research · 2025Article
- Recommendations for dengue vaccine implementation in the elderly population.Therapeutic advances in vaccines and immunotherapy · 2025Review
- Dengue fever in hyperglycemic patients: an emerging public health concern demanding eyes on the effective management strategies.Health science reports · 2024Article
- Dengue haemorrhagic fever in chronic kidney disease and heart failure: challenges in fluid management.Tropical medicine and health · 2024Review
- Severe dengue in the intensive care unit.Journal of intensive medicine · 2024Review
- Genetic Association Studies ofDiagnostics (Basel, Switzerland) · 2023Article
- Adipokine levels and their association with clinical disease severity in patients with dengue.PLoS neglected tropical diseases · 2023Article
- Bridging the immunogenicity of a tetravalent dengue vaccine (TAK-003) from children and adolescents to adults.NPJ vaccines · 2023Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Progression to severe organ involvement due to dengue infection has been associated with severe dengue disease, intensive care treatment, and mortality. However, there is a lack of understanding of the impact of pre-existing comorbidities and other risk factors of severe organ involvement among dengue adults. The aim of this retrospective case-control study is to characterize and identify risk factors that predispose dengue adults at risk of progression with severe organ involvement. This study involved 174 dengue patients who had progressed with severe organ involvement and 865 dengue patients without severe organ involvement, matched by the year of presentation of the cases, who were admitted to Tan Tock Seng Hospital between year 2005 and 2008. Age group of 60 years or older, diabetes, cardiac disorders, asthma, and having two or more pre-existing comorbidities were independent risk factors of severe organ involvement. Abdominal pain, clinical fluid accumulation, and hematocrit rise and rapid platelet count drop at presentation were significantly associated with severe organ involvement. These risk factors, when validated in a larger study, will be useful for triage by clinicians for prompt monitoring and clinical management at first presentation, to minimize the risk of severe organ involvement and hence, disease severity.
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