ArticleScientific reports2017
Pulsation-limited oxygen diffusion in the tumour microenvironment.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
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- Integrative systems-level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors.Molecular oncology · 2025Article
- Multi-pathway oxidative stress amplification via controllably targeted nanomaterials for photoimmunotherapy of tumors.Journal of nanobiotechnology · 2025Article
- Oscillatory hypoxia induced gene expression predicts low survival in human breast cancer patients.Molecular carcinogenesis · 2024Article
- Stable and oscillatory hypoxia differentially regulate invasibility of breast cancer associated fibroblasts.Mechanobiology in medicine · 2024Article
- Computational modeling of the physical features that influence breast cancer invasion into adipose tissue.APL bioengineering · 2024Article
- Aggression to Biomembranes by Hydrophobic Tail Chains under the Stimulus of Reductant.Molecules (Basel, Switzerland) · 2024Article
- Computational modeling of the physical features that influence breast cancer invasion into adipose tissue.ArXiv · 2024Article
- Mass Transport Model of Radiation Response: Calibration and Application to Chemoradiation for Pancreatic Cancer.International journal of radiation oncology, biology, physics · 2022Article
- Nuclear Medicine Imaging Procedures in Oncology.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Multicompartment modeling of protein shedding kinetics during vascularized tumor growth.Scientific reports · 2020Article
- The control of acidity in tumor cells: a biophysical model.Scientific reports · 2020Article
- The Spatial and Genomic Hierarchy of Tumor Ecosystems Revealed by Single-Cell Technologies.Trends in cancer · 2019Review
- A Metabolism Toolbox for CAR T Therapy.Frontiers in oncology · 2019Review
- Differential Oxygenation in Tumor Microenvironment Modulates Macrophage and Cancer Cell Crosstalk: Novel Experimental Setting and Proof of Concept.Frontiers in oncology · 2019Article
- Study of an Oxygen Supply and Oxygen Saturation Monitoring System for Radiation Therapy Associated with the Active Breathing Coordinator.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypoxia is central to tumour evolution, growth, invasion and metastasis. Mathematical models of hypoxia based on reaction-diffusion equations provide seemingly incomplete descriptions as they fail to predict the measured oxygen concentrations in the tumour microenvironment. In an attempt to explain the discrepancies, we consider both the inhomogeneous distribution of oxygen-consuming cells in solid tumours and the dynamics of blood flow in the tumour microcirculation. We find that the low-frequency oscillations play an important role in the establishment of tumour hypoxia. The oscillations interact with consumption to inhibit oxygen diffusion in the microenvironment. This suggests that alpha-blockers-a class of drugs used to treat hypertension and stress disorders, and known to lower or even abolish low-frequency oscillations of arterial blood flow -may act as adjuvant drugs in the radiotherapy of solid tumours by enhancing the oxygen effect.
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