Evidence map›Paper›PMID 28045062›Full record

ArticleScientific reports2017

Modifying effect of mouse double minute-2 promoter variants on risk of recurrence for patients with squamous cell carcinoma of oropharynx.

Yang Zhang, Erich M Sturgis, Yuncheng Li, Qingyi Wei, Zhigang Huang, Guojun Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Yang ZhangDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Erich M SturgisDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Yuncheng LiDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Qingyi WeiDuke Cancer Institute, Duke University Medical Center, Durham, NC 27710, USA.
Zhigang HuangDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Guojun LiDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
The University of Texas MD Anderson Cancer Center · USDuke Medical Center · USUnion Hospital · CN

Funding

Molecular Epidemiology of Head and Neck CancerR01ES011740 · NIEHS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WEI, QINGYI · 2001 to 2012
$6.3M
Predictors of HPV16 Status and Outcomes of Oropharyngeal Cancer PatientsK07CA133099 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LI, GUOJUN · 2008 to 2012
$680k
Inflammatory Response miRNAs Predict HPV-associated Oropharyngeal Cancer OutcomeR03CA186261 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LI, GUOJUN · 2015 to 2016
$164k
Use of Serum HPV16 DNA as a Marker for Oropharyngeal Cancer RecurrenceR03CA128110 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI STURGIS, ERICH MADISON · 2007 to 2008
$154k
Cytokine Variants as Predictors of HPV-16 Status & Outcome of Oropharyngeal CanceR03CA135679 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LI, GUOJUN · 2008 to 2009
$154k
NCI NIH HHS K07 CA133099NCI NIH HHS R03 CA128110NCI NIH HHS R03 CA135679NCI NIH HHS R03 CA186261NIEHS NIH HHS R01 ES011740
6 · The paper itself

Abstract

Functional mouse double minute-2 (MDM2) promoter variants may alter MDM2 expression and thus affect radiotherapy response and prognosis of squamous cell carcinoma of oropharynx (SCCOP). Thus we assessed association of 2 functional MDM2 promoter variants with recurrence risk of SCCOP. The disease-free survival (DFS) of patients with MDM2rs2279744 TT or MDM2rs937283 AA genotypes was significantly reduced compared with that of patients with corresponding GT/GG or AG/GG genotypes. Multivariable analysis showed patients with TT or AA genotypes had a significantly higher risk of SCCOP recurrence than those with corresponding GT/GG or AG/GG genotypes did. Furthermore, patients with combined risk genotypes of the 2 polymorphisms had significantly worse DFS and a higher recurrence risk than patients with fewer combined risk genotypes did (P

Indexed as

GenotypeAnimalsCarcinoma, Squamous CellEffect Modifier, EpidemiologicFemaleFollow-Up StudiesHead and Neck NeoplasmsHuman papillomavirus 16HumansMaleMiceMiddle AgedNeoplasm Recurrence, LocalOropharyngeal NeoplasmsPapillomavirus InfectionsPolymorphism, Single NucleotideMdm2 protein, mouseProto-Oncogene Proteins c-mdm2

Identifiers

PMID28045062
PMCPMC5206622
OpenAlexW2567553212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.