ArticleScientific reports2017
The Three-Herb Formula Shuang-Huang-Lian stabilizes mast cells through activation of mitochondrial calcium uniporter.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- The Anaphylactic and Anti-allergenic Properties of Shuanghuanglian: A Review.Combinatorial chemistry & high throughput screening · 2026Review
- Safflower yellow inChinese herbal medicines · 2026Article
- Mitochondrial calcium uniporter complex: An emerging therapeutic target for cardiovascular diseases (Review).International journal of molecular medicine · 2025Review
- MCU complex: Exploring emerging targets and mechanisms of mitochondrial physiology and pathology.Journal of advanced research · 2025Review
- Effect of Small-Molecule Natural Compounds on Pathologic Mast Cell/Basophil Activation in Allergic Diseases.Cells · 2024Review
- Arvanil induces ferroptosis of hepatocellular carcinoma by binding to MICU1.Cancer gene therapy · 2024Article
- Allergenic protein-induced type I hypersensitivity models: a review.Frontiers in allergy · 2024Review
- Human Umbilical Cord Mesenchymal Stem Cell Therapy Mitigates Interstitial Cystitis by Inhibiting Mast Cells.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Forsythiasides-Rich Extract From Forsythiae Fructus Inhibits Mast Cell Degranulation by Enhancing Mitochondrial CaFrontiers in pharmacology · 2021Article
- Compound Kushen Injection Induces Immediate Hypersensitivity Reaction Through Promoting the Production of Platelet-Activating Factor viaFrontiers in pharmacology · 2021Article
- OUTBREAK of novel corona virus disease (COVID-19): Antecedence and aftermath.European journal of pharmacology · 2020Review
- Penicillin causes non-allergic anaphylaxis by activating the contact system.Scientific reports · 2020Article
- Regulation of Mitochondrial Quality Control by Natural Drugs in the Treatment of Cardiovascular Diseases: Potential and Advantages.Frontiers in cell and developmental biology · 2020Review
- Qing-Kai-Ling Injection Induces Immediate Hypersensitivity ReactionFrontiers in pharmacology · 2019Article
- Shuang-Huang-Lian Attenuates Airway Hyperresponsiveness and Inflammation in a Shrimp Protein-Induced Murine Asthma Model.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Shuang-Huang-Lian injection induces an immediate hypersensitivity reaction via C5a but not IgE.Scientific reports · 2018Article
- Shuang-Huang-Lian prevents basophilic granulocyte activation to suppress Th2 immunity.BMC complementary and alternative medicine · 2018Article
- Ameliorative effects of type-A procyanidins polyphenols from cinnamon bark in compound 48/80-induced mast cell degranulation.Anatomy & cell biology · 2017Article
- Use of the relative release index for histamine in LAD2 cells to evaluate the potential anaphylactoid effects of drugs.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mast cells (MCs) are key effector cells of IgE-FcεRI- or MrgprX2-mediated signaling event. Shuang-Huang-Lian (SHL), a herbal formula from Chinese Pharmacopoeia, has been clinically used in type I hypersensitivity. Our previous study demonstrated that SHL exerted a non-negligible effect on MC stabilization. Herein, we sought to elucidate the molecular mechanisms of the prominent anti-allergic ability of SHL. MrgprX2- and IgE-FcεRI-mediated MC activation in vitro and in vivo models were developed by using compound 48/80 (C48/80) and shrimp tropomyosin (ST), respectively. Our data showed that SHL markedly dampened C48/80- or ST-induced MC degranulation in vitro and in vivo. Mechanistic study indicated that cytosolic Ca
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