Evidence map›Paper›PMID 28044466›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2017

Brief Communication: Plasma lipid oxidation predicts atherosclerotic status better than cholesterol in diabetic apolipoprotein E deficient mice.

Karen Ekkelund Petersen, Jens Lykkesfeldt, Kirsten Raun, Günaj Rakipovski

Abstract read
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Karen Ekkelund Petersen1 Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-1870 Frederiksberg C, Denmark.
Jens Lykkesfeldt1 Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-1870 Frederiksberg C, Denmark.
Kirsten Raun2 Department of Incretin and Obesity Pharmacology, Novo Nordisk A/S, DK-2760 Maaloev, Denmark.
Günaj Rakipovski3 Department of Diabetes Pharmacology, Novo Nordisk A/S, DK-2760 Maaloev, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increased levels of oxidative stress have been suggested to play a detrimental role in the development of diabetes-related vascular complications. Here, we investigated whether the concentration of malondialdehyde, a marker of lipid oxidation correlated to the degree of aortic plaque lesions in a proatherogenic diabetic mouse model. Three groups of apolipoprotein E knockout mice were studied for 20 weeks, a control, a streptozotocin-induced diabetic, and a diabetic enalapril-treated group. Enalapril was hypothesized to lower oxidative stress level and thus the plaque burden. Both diabetic groups were significantly different from the control group as they had higher blood glucose, HbA

Indexed as

AnimalsAortaApolipoproteins ECholesterolDiabetes Mellitus, ExperimentalEnalaprilLipid MetabolismLipidsLipoproteins, HDLLipoproteins, LDLMaleMalondialdehydeMice, KnockoutOxidation-ReductionPlaque, AtheroscleroticApolipoproteins ECholesterolEnalaprilLipidsLipoproteins, HDLLipoproteins, LDLMalondialdehydeAPOE(-/-) miceatherosclerosisDiabeteslipid oxidationmalondialdehydeoxidative stress

Identifiers

PMID28044466
PMCPMC5206975

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.