ReviewAmerican journal of reproductive immunology (New York, N.Y. : 1989)2017
Current concepts in maternal-fetal immunology: Recognition and response to microbial pathogens by decidual stromal cells.
Review in American journal of reproductive immunology (New York, N.Y. : 1989), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 42 citations in OpenAlex.
- Heterogeneity in inflammatory responses to endotoxin at the fetomaternal interface.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Article
- Deciphering maternal-fetal cross-talk in the human placenta during parturition using single-cell RNA sequencing.Science translational medicine · 2024Article
- Chorioamnionitis: An Update on Diagnostic Evaluation.Biomedicines · 2023Review
- Association between a Mixture of Per- and Polyfluoroalkyl Substances (PFAS) and Inflammatory Biomarkers in the Atlanta African American Maternal-Child Cohort.Environmental science & technology · 2023Article
- Fetal membrane at the feto-maternal interface: An underappreciated and understudied intrauterine tissue.Placenta and reproductive medicine · 2022Article
- Placental extracellular vesicles-associated microRNA-519c mediates endotoxin adaptation in pregnancy.American journal of obstetrics and gynecology · 2021Article
- Distinct Group BInfection and immunity · 2021Article
- Human Tissue-Resident Memory T Cells in the Maternal-Fetal Interface. Lost Soldiers or Special Forces?Cells · 2020Review
- Article
- Human Chorionic Gonadotropin modulates CXCL10 Expression through Histone Methylation in human decidua.Scientific reports · 2020Article
- DECONSTRUCTING EXTRAPLACENTAL MEMBRANES TO UNDERSTAND BACTERIAL CHORIOAMNIONITIS.Transactions of the American Clinical and Climatological Association · 2020Article
- Immunobiology of Acute Chorioamnionitis.Frontiers in immunology · 2020Review
- Modulation of Death and Inflammatory Signaling in Decidual Stromal Cells following Exposure to Group BInfection and immunity · 2019Article
- Gasdermin D: Evidence of pyroptosis in spontaneous preterm labor with sterile intra-amniotic inflammation or intra-amniotic infection.American journal of reproductive immunology (New York, N.Y. : 1989) · 2019Article
- Regulation of inflammation during gestation and birth outcomes: Inflammatory cytokine balance predicts birth weight and length.American journal of human biology : the official journal of the Human Biology Council · 2019Article
- Inhibition of the NLRP3 inflammasome can prevent sterile intra-amniotic inflammation, preterm labor/birth, and adverse neonatal outcomes†.Biology of reproduction · 2019Article
- Clinical chorioamnionitis at term IX: in vivo evidence of intra-amniotic inflammasome activation.Journal of perinatal medicine · 2019Article
- MicroRNA-Mediated Control of Inflammation and Tolerance in Pregnancy.Frontiers in immunology · 2019Review
- Genetically distinct Group B Streptococcus strains induce varying macrophage cytokine responses.PloS one · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Chorioamnionitis is an acute inflammation of the gestational (extraplacental) membranes, most commonly caused by ascending microbial infection. It is associated with adverse neonatal outcomes including preterm birth, neonatal sepsis, and cerebral palsy. The decidua is the outermost layer of the gestational membranes and is likely an important initial site of contact with microbes during ascending infection. However, little is known about how decidual stromal cells (DSCs) respond to microbial threat. Defining the contributions of individual cell types to the complex medley of inflammatory signals during chorioamnionitis could lead to improved interventions aimed at halting this disease. We review available published data supporting the role for DSCs in responding to microbial infection, with a special focus on their expression of pattern recognition receptors and evidence of their responsiveness to pathogen sensing. While DSCs likely play an important role in sensing and responding to infection during the pathogenesis of chorioamnionitis, important knowledge gaps and areas for future research are highlighted.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.