ArticleArtificial organs2017
A Cellular Model of Shear-Induced Hemolysis.
Article in Artificial organs, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 71 citations in OpenAlex.
- Shear-Responsive Red Blood Cell Carriers for Targeted Drug Delivery to Constricted Arteries.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Red blood cell deformation in a microfluidic sudden expansion at supraphysiological strain rates.Biophysical journal · 2026Article
- From Early Models to Emerging Trends: The Evolution of Computational Hemolysis Prediction.Annals of biomedical engineering · 2026Review
- The Challenges of Vascular Implants: Regulatory Strategies and Biological Responses.Small science · 2025Review
- Multi-scale simulation of red blood cell trauma in large-scale high-shear flows after Norwood operation.Computer methods and programs in biomedicine · 2025Article
- Effect of intercellular collisions on red blood cell membrane damage.Scientific reports · 2025Article
- CFD-Based Hemolysis Study of Fontan Cavopulmonary Assist Device Using Kriging Surrogate Modeling.Artificial organs · 2025Article
- Recent advances in microscale techniques for red blood cells manipulation.Biomicrofluidics · 2025Review
- The dynamics of red blood cells traversing slits of mechanical heart valves under high shear.Biophysical journal · 2024Article
- Investigating the effect of turbulence on hemolysis through cell-resolved fluid-structure interaction simulations of individual red blood cells.Physical review fluids · 2024Article
- [Progress in the analysis of hemolysis and coagulation models for interventional micro-axial flow blood pumps].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Review
- Analysis of the Suitability of an Effective Viscosity to Represent Interactions Between Red Blood Cells in Shear Flow.Journal of biomechanical engineering · 2024Article
- Coarse-grained molecular simulation of extracellular vesicle squeezing for drug loading.Physical chemistry chemical physics : PCCP · 2023Article
- Cell-scale hemolysis evaluation of intervenient ventricular assist device based on dissipative particle dynamics.Frontiers in physiology · 2023Article
- Computational fluid dynamics analysis and experimental hemolytic performance of three clinical centrifugal blood pumps: Revolution, Rotaflow and CentriMag.Medicine in novel technology and devices · 2022Article
- A cell-resolved, Lagrangian solver for modeling red blood cell dynamics in macroscale flows.Journal of computational physics · 2022Article
- A New EvaluationThe journal of extra-corporeal technology · 2022Article
- Models of Shear-Induced Platelet Activation and Numerical Implementation With Computational Fluid Dynamics Approaches.Journal of biomechanical engineering · 2022Article
- Hemolytic Performance in Two Generations of the Sputnik Left Ventricular Assist Device: A Combined Numerical and Experimental Study.Journal of functional biomaterials · 2022Article
- A numerical study on drug deliveryNanoscale · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A novel model is presented to study red blood cell (RBC) hemolysis at cellular level. Under high shear rates, pores form on RBC membranes through which hemoglobin (Hb) leaks out and increases free Hb content of plasma leading to hemolysis. By coupling lattice Boltzmann and spring connected network models through immersed boundary method, we estimate hemolysis of a single RBC under various shear rates. First, we use adaptive meshing to find local strain distribution and critical sites on RBC membranes, and then we apply underlying molecular dynamics simulations to evaluate damage. Our approach comprises three sub-models: defining criteria of pore formation, calculating pore size, and measuring Hb diffusive flux out of pores. Our damage model uses information of different scales to predict cellular level hemolysis. Results are compared with experimental studies and other models in literature. The developed cellular damage model can be used as a predictive tool for hydrodynamic and hematologic design optimization of blood-wetting medical devices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.