Evidence map›Paper›PMID 28044311›Full record

ReviewThe Journal of physiology2017

Effects of hypercapnia on the lung.

Masahiko Shigemura, Emilia Lecuona, Jacob I Sznajder

Open access · greenAbstract readReview
In one paragraph

Review in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 64 citations in OpenAlex.

  1. Impact of draining cannula position and configuration under high-flow extracorporeal COJournal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2026
    Article
  2. Hypercapnia Effects on Lung Function.Comprehensive Physiology · 2026
    Review
  3. Article
  4. Review
  5. Impact of early PaCOAnnals of intensive care · 2025
    Article
  6. COMolecules (Basel, Switzerland) · 2025
    Review
  7. Carbon dioxide regulatesInfection and immunity · 2025
    Article
  8. Article
  9. Risks for prolonged mechanical ventilation and reintubation after cervical malignant tumor surgery: a nested case-control study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024
    Article
  10. Review
  11. TargetingMicrobiology (Reading, England) · 2024
    Review
  12. Article
  13. Lowering PRespiratory care · 2023
    Article
  14. Review
  15. Impact of Arterial CORespiratory care · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Hypercapnia from Physiology to Practice.International journal of clinical practice · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Masahiko ShigemuraDivision of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL, USA.
Emilia LecuonaDivision of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL, USA.
Jacob I SznajderDivision of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-2089-4764
Northwestern University · US

Funding

Role of LUBAC and Na K-ATPase in Acute Lung InjuryP01HL071643 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHANDEL, NAVDEEP S · 2003 to 2019
$30.8M
Tissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GR Scott Budinger · 2015 to 2026
$26.9M
The injurious effects of hypercapnia on the alveolar epitheliumR01HL085534 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2006 to 2018
$4.9M
Role and Regulation of Sodium, Potasium ATPase in LungR37HL048129 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2008 to 2017
$4.0M
NHLBI NIH HHS P01 HL071643NHLBI NIH HHS R01 HL085534NHLBI NIH HHS R37 HL048129NIA NIH HHS P01 AG049665
6 · The paper itself

Abstract

Gases are sensed by lung cells and can activate specific intracellular signalling pathways, and thus have physiological and pathophysiological effects. Carbon dioxide (CO

Indexed as

AnimalsCarbon DioxideHumansHypercapniaImmunity, InnateLungPulmonary AlveoliCarbon Dioxideairway functionalveolar epithelial functioncarbon dioxidehypercapniainjury and repairinnate immunity and host defense

Identifiers

PMID28044311
PMCPMC5390878
OpenAlexW2566396792

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.