Evidence map›Paper›PMID 28044215›Full record

ArticleInflammopharmacology2017

Mixed effects of caffeic acid phenethyl ester (CAPE) on joint inflammation, bone loss and gastrointestinal inflammation in a murine model of collagen antibody-induced arthritis.

Bonnie Williams, Eleni Tsangari, Romany Stansborough, Victor Marino, Melissa Cantley, Anak Dharmapatni, Rachel Gibson, Egon Perilli, Tania Crotti

Abstract read
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In one paragraph

Article in Inflammopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Bonnie WilliamsAdelaide Medical School, The University of Adelaide, Adelaide, SA, Australia. bonnie.williams@adelaide.edu.au.ORCID http://orcid.org/0000-0002-2356-105X
Eleni TsangariAdelaide Medical School, The University of Adelaide, Adelaide, SA, Australia.
Romany StansboroughAdelaide Medical School, The University of Adelaide, Adelaide, SA, Australia.
Victor MarinoSchool of Dentistry, The University of Adelaide, Adelaide, SA, Australia.
Melissa CantleyAdelaide Medical School, The University of Adelaide, Adelaide, SA, Australia.
Anak DharmapatniAdelaide Medical School, The University of Adelaide, Adelaide, SA, Australia.
Rachel GibsonAdelaide Medical School, The University of Adelaide, Adelaide, SA, Australia.
Egon PerilliSchool of Computer Science, Engineering and Mathematics, Flinders University, Adelaide, SA, Australia.
Tania CrottiAdelaide Medical School, The University of Adelaide, Adelaide, SA, Australia.
The University of Adelaide · AUFlinders University · AUUniversity of South Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effect of caffeic acid phenethyl ester (CAPE) on local and systemic inflammation and bone loss in collagen antibody-induced arthritis (CAIA) mice.

methodsFour groups of mice (n = 8 per group) were allocated; control, CAPE (1 mg/kg), CAIA and CAIA + CAPE (1 mg/kg). Local inflammation and bone loss were evaluated using clinical paw scores, in vivo micro-computed tomography (micro-CT), histological assessment and tartrate-resistant acid phosphatase (TRAP) staining. Serum levels of C-reactive protein (CRP) and C-terminal telopeptide (CTX-1) were measured by ELISA. Jejunum and colon sections were evaluated histopathologically for damage and toxicity.

resultsGreater paw scores and percentage change in paw volume were observed in CAIA + CAPE compared to the control groups (p < 0.05). Bone volume over time remained unchanged (p = 0.94) and the number of multinucleated TRAP-positive cells was greatest in CAIA + CAPE mice (p < 0.05). CRP and CTX-1 levels did not differ between groups. CAIA + CAPE mice exhibited lower colon toxicity scores and a reduced percentage of cavitated goblet cells in the colon crypts compared with CAIA mice (p = 0.026 and p = 0.003, respectively). Histopathology in the jejunum was not altered.

conclusionCAPE did not reduce paw inflammation or bone loss in CAIA mice. CAPE reduced histopathological changes in the colon of CAIA mice.

Indexed as

AnimalsArthritis, ExperimentalBone ResorptionCaffeic AcidsCollagenGastrointestinal TractInflammationJointsMiceMice, Inbred BALB CPhenylethyl AlcoholRandom AllocationTomography, X-Ray ComputedTreatment Outcomecaffeic acid phenethyl esterCaffeic AcidsCollagenPhenylethyl AlcoholBoneCAIACAPEGastrointestinal tractInflammatory arthritisMicro-CT

Identifiers

PMID28044215
OpenAlexW2565958645

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.