Evidence map›Paper›PMID 28042859›Full record

ArticleMolecules (Basel, Switzerland)2016

A Novel Role of Silibinin as a Putative Epigenetic Modulator in Human Prostate Carcinoma.

Ioannis Anestopoulos, Aristeidis P Sfakianos, Rodrigo Franco, Katerina Chlichlia, Mihalis I Panayiotidis, David J Kroll, Aglaia Pappa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 57 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Ioannis AnestopoulosDepartment of Molecular Biology and Genetics, Democritus University of Thrace, University Campus, Dragana, 68100 Alexandroupolis, Greece. i.anestopoulos@yahoo.com.
Aristeidis P SfakianosDepartment of Molecular Biology and Genetics, Democritus University of Thrace, University Campus, Dragana, 68100 Alexandroupolis, Greece. aristidis.sfakianos@postgrad.manchester.ac.uk.
Rodrigo FrancoRedox Biology Center, School of Veterinary Medicine & Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA. rodrigo.franco@unl.edu.
Katerina ChlichliaDepartment of Molecular Biology and Genetics, Democritus University of Thrace, University Campus, Dragana, 68100 Alexandroupolis, Greece. achlichl@mbg.duth.gr.
Mihalis I PanayiotidisDepartment of Applied Sciences, Northumbria University, Newcastle Upon Tyne NE1 8ST, UK. m.panagiotidis@northumbria.ac.uk.
David J KrollDepartment of Pharmaceutical Sciences, College of Science & Technology, Biomanufacturing Research Institute and Technology Enterprise (BRITE), North Carolina Central University, Durham, NC 27707, USA. davidjkroll@gmail.com.
Aglaia PappaDepartment of Molecular Biology and Genetics, Democritus University of Thrace, University Campus, Dragana, 68100 Alexandroupolis, Greece. apappa@mbg.duth.gr.
Democritus University of Thrace · GRNorth Carolina Central University · USNorthumbria University · GBUniversity of Nebraska–Lincoln · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Silibinin, extracted from milk thistle (

Indexed as

Antineoplastic AgentsAntioxidantsCell Line, TumorDNA (Cytosine-5-)-MethyltransferasesEnhancer of Zeste Homolog 2 ProteinEpigenesis, GeneticGene Expression Regulation, NeoplasticHistone Deacetylase 1Histone Deacetylase 2HistonesHumansMaleMethylationNeoplasm ProteinsPhosphorylationPolycomb Repressive Complex 2Antineoplastic AgentsAntioxidantsDNA (Cytosine-5-)-MethyltransferasesEED protein, humanEnhancer of Zeste Homolog 2 ProteinEZH2 protein, humanHDAC1 protein, humanHDAC2 protein, humanHistone Deacetylase 1Histone Deacetylase 2HistonesNeoplasm ProteinsPolycomb Repressive Complex 2Proto-Oncogene Proteins c-aktSilybinSilymarinSUZ12 protein, humanTranscription FactorsDNMTepigeneticsEZH2H3K27me3HDAChistone methylationPRC2prostate cancersilibinin

Identifiers

PMID28042859
PMCPMC6155798
OpenAlexW2563749186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.