ArticleEndocrine2017
TSH increment and the risk of incident type 2 diabetes mellitus in euthyroid subjects.
Article in Endocrine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Association between thyroid dysfunction and type 2 diabetes: a meta-analysis of prospective observational studies.BMC medicine · 2021Pooled it
- Thyroid-stimulating hormone levels in the normal range and incident type 2 diabetes mellitus.Acta diabetologica · 2019Pooled it
- Hashimoto's thyroiditis and congenital long QT syndrome: a dangerous addition causing torsades-case report.European heart journal. Case reports · 2025Article
- Changes in Thyroid Function and Autoimmunity in Older Individuals: Longitudinal Analysis of the Whickham Cohort.The Journal of clinical endocrinology and metabolism · 2025Article
- Thyrotropin exacerbates insulin resistance by triggering macrophage inflammation in subclinical hypothyroidism.Experimental & molecular medicine · 2025Article
- A Comprehensive Mendelian Randomization Study Investigating Multiple Exposures and Outcomes: Focusing on Nontoxic Goitre and Type 2 Diabetes Mellitus.Clinical endocrinology · 2025Article
- Association between central thyroid hormone sensitivity and prediabetes: Tehran thyroid study.Frontiers in endocrinology · 2025Article
- Relationship between thyroid-stimulating hormone and blood lipids in patients with first-episode depression.BMC psychiatry · 2024Article
- Thyroid Hormones and Diabetes in Euthyroid Hispanic/Latino Adults of Diverse Backgrounds: HCHS/SOL.Journal of the Endocrine Society · 2024Article
- Article
- Association Between Sensitivity to Thyroid Hormone Indices and Diabetic Retinopathy in Euthyroid Patients with Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- The effect of hypothyroidism on the risk of diabetes and its microvascular complications: a Mendelian randomization study.Frontiers in endocrinology · 2023Article
- The Correlation Between Thyroid Parameters and the Ratios of Neutrophil/Lymphocyte and Platelet/Lymphocyte in Euthyroid Type 2 Diabetic Patients.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Retrospective cohort analysis comparing changes in blood glucose level and body composition according to changes in thyroid-stimulating hormone level.Journal of diabetes · 2022Article
- Impaired Sensitivity to Thyroid Hormones Is Associated With Elevated Blood Glucose in Coronary Heart Disease.Frontiers in endocrinology · 2022Article
- Relationship of TSH Levels with Cardiometabolic Risk Factors in US Youth and Reference Percentiles for Thyroid Function.The Journal of clinical endocrinology and metabolism · 2021Article
- High-Normal Serum Thyrotropin Levels Increased the Risk of Non-Alcoholic Fatty Liver Disease in Euthyroid Subjects with Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Sensitivity to Thyroid Hormones and Risk of Prediabetes: A Cross-Sectional Study.Frontiers in endocrinology · 2021Article
- TSH Combined with TSHR Aggravates Diabetic Peripheral Neuropathy by Promoting Oxidative Stress and Apoptosis in Schwann Cells.Oxidative medicine and cellular longevity · 2021Article
- Relationship between Free Thyroxine and Islet Beta-cell Function in Euthyroid Subjects.Current medical science · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThyroid function is known to influence glucose metabolism, and thyroid-stimulating hormone is the most useful parameter in screening for thyroid dysfunction. Therefore, the aim of this study was to investigate the incidence of type 2 diabetes according to baseline thyroid-stimulating hormone level and thyroid-stimulating hormone change in euthyroid subjects.
methodsWe identified and enrolled 17,061 euthyroid subjects without diabetes among participants who had undergone consecutive thyroid function tests between 2006 and 2012 as a part of yearly health check-up program. Thyroid-stimulating hormone changes were determined by subtracting baseline thyroid-stimulating hormone level from thyroid-stimulating hormone level at 1 year before diagnosis of diabetes or at the end of follow-up in subjects who did not develope diabetes.
resultsDuring 84,595 person-years of follow-up, there were 956 new cases of type 2 diabetes. Cox proportional hazards models showed the risk of incident type 2 diabetes was significantly increased with each 1 μIU/mL increment in TSH after adjustment for multiple confounding factors (hazard ratio = 1.13, 95% confidence interval: 1.07-1.20, P < 0.001). Compared with individuals in the lowest tertile (-4.08 to 0.34 μIU/mL), those in the highest thyroid-stimulating hormone change tertile (0.41-10.84 μIU/mL) were at greater risk for incident type 2 diabetes (hazard ratio = 1.25, 95% confidence interval: 1.05-1.48, P for trend = 0.011). However, baseline thyroid-stimulating hormone level and tertile were not associated with the risk for diabetes.
conclusionsProminent increase in thyroid-stimulating hormone concentration can be an additional risk factor for the development of type 2 diabetes in euthyroid subjects.
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