Evidence map›Paper›PMID 28042510›Full record

ArticleAmerican journal of cancer research2016

Molecular characterization of paediatric glioneuronal tumours with neuropil-like islands: a genome-wide copy number analysis.

Laura Giunti, Anna Maria Buccoliero, Marilena Pantaleo, Maurizio Lucchesi, Aldesia Provenzano, Viviana Palazzo, Silvia Guarducci, Milena Guidi, Lorenzo Genitori, Orsetta Zuffardi and 2 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of cancer research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Laura GiuntiMedical Genetics Unit, Meyer Children's University Hospital Viale Pieraccini 2450139, Florence, Italy.
Anna Maria BuccolieroAnatomic Pathology Unit, Meyer Children's University Hospital Viale Pieraccini 2450139, Florence, Italy.
Marilena PantaleoMedical Genetics Unit, Meyer Children's University Hospital Viale Pieraccini 2450139, Florence, Italy.
Maurizio LucchesiNeuro-Oncology Unit, Department of Pediatric Oncology, Meyer Children's University Hospital Viale Pieraccini 2450139, Florence, Italy.
Aldesia ProvenzanoMedical Genetics Unit, Department of Clinical and Experimental Biomedical Sciences "Mario Serio", University of Florence Viale Morgagni 5050134, Florence, Italy (S.G.).
Viviana PalazzoMedical Genetics Unit, Department of Clinical and Experimental Biomedical Sciences "Mario Serio", University of Florence Viale Morgagni 5050134, Florence, Italy (S.G.).
Silvia GuarducciMedical Genetics Unit, Meyer Children's University Hospital Viale Pieraccini 2450139, Florence, Italy.
Milena GuidiNeuro-Oncology Unit, Department of Pediatric Oncology, Meyer Children's University Hospital Viale Pieraccini 2450139, Florence, Italy.
Lorenzo GenitoriNeurosurgery Unit, Department of Neuroscience, Meyer Children's University Hospital Viale Pieraccini 2450139, Florence, Italy.
Orsetta ZuffardiDepartment of Molecular Medicine, University of Pavia Viale Forlanini 1427100, Pavia, Italy.
Iacopo SardiNeuro-Oncology Unit, Department of Pediatric Oncology, Meyer Children's University Hospital Viale Pieraccini 2450139, Florence, Italy.
Sabrina GiglioMedical Genetics Unit, Meyer Children's University HospitalViale Pieraccini 2450139, Florence, Italy; Medical Genetics Unit, Department of Clinical and Experimental Biomedical Sciences "Mario Serio", University of FlorenceViale Morgagni 5050134, Florence, Italy (S.G.).
Meyer Children's Hospital · ITUniversity of Florence · ITUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paediatric glioneuronal tumour with neuropil-like islands (GTNI) is a rare neoplasm of neuronal differentiation and diffusely infiltrating astroglial and oligodendrocyte-like components. The 2007 World Health Organization classification of central nervous system tumours considered it as a pattern variation of anaplastic astrocytoma. There are few data on paediatric GTNI probably both for their rarity and variable clinical aggressiveness. We studied by SNP/CGH array four tumour samples of GTNI from two males and two females (one new-born and three children aged from 4 to 8 years), in order to identify any possible common genomic alteration. All patients received chemo- and radiotherapy after their surgical treatment. No genomic instability nor recurrent alterations have been demonstrated in two of our GTNI cases. In the remaining two, we detected a mosaic trisomy 8 (15-20%) in one case, and an amplification at 5q14.1 involving

Indexed as

amplificationcentral nervous tumours (CNS)common genomic alterationcopy number variations (CNVs)Database of Genomic Variants (DGV)Glioneuronal tumour with neuropil-like islands (GTNI)mosaicismpaediatric brain tumoursSNP/CGH arrayvariation of anaplastic astrocytoma

Identifiers

PMID28042510
PMCPMC5199764
OpenAlexW2587082240

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.