ArticlePharmacy practice
Potentially inappropriate prescribing andthe risk of adverse drug reactions in critically ill older adults.
Article in Pharmacy practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Medication-related problems in critical care survivors: a systematic review.European journal of hospital pharmacy : science and practice · 2023Pooled it
- Potentially inappropriate prescribing and its associations with health-related and system-related outcomes in hospitalised older adults: A systematic review and meta-analysis.British journal of clinical pharmacology · 2021Pooled it
- Medication Appropriateness and Potentially Inappropriate Medications in Older Critical Care Patients: A Scoping Review.Drugs & aging · 2026Review
- Article
- Potentially inappropriate medicine use and predicting risk factors in hospitalized older adult patients: findings of a prospective observational study from Ethiopia.Journal of pharmaceutical policy and practice · 2023Article
- Overuse of medications in low- and middle-income countries: a scoping review.Bulletin of the World Health Organization · 2023Article
- Medication use problems among older adults at a primary care: A narrative of literature review.Aging medicine (Milton (N.S.W)) · 2022Review
- Potentially inappropriate medication use in hospitalized elderly patients.Revista da Associacao Medica Brasileira (1992) · 2022Article
- A machine learning-based risk warning platform for potentially inappropriate prescriptions for elderly patients with cardiovascular disease.Frontiers in pharmacology · 2022Article
- Potentially inappropriate medication use among older adult patients on follow-up at the chronic care clinic of a specialized teaching hospital in Ethiopia. A cross-sectional study.BMC geriatrics · 2021Article
- Prevalence, characteristics and predicting risk factors of adverse drug reactions among hospitalized older adults: A systematic review and meta-analysis.SAGE open medicine · 2021Review
- Prevalence, Incidence, and Characteristics of Adverse Drug Reactions Among Older Adults Hospitalized at Mbarara Regional Referral Hospital, Uganda: A Prospective Cohort Study.Clinical interventions in aging · 2021Article
- Appropriateness of Medication Prescribing in Hospitalized Older Adults in a Tertiary Teaching Hospital in the Philippines: A Cross-Sectional Study.Drugs - real world outcomes · 2020Article
- Use of potentially inappropriate medication and polypharmacy in older adults: a repeated cross-sectional study.BMC geriatrics · 2020Article
- American Geriatrics Society-Beers Criteria and adverse drug reactions: a comparative cross-sectional study of Nigerian and South African older inpatients.Clinical interventions in aging · 2018Article
- Polypharmacy leads to increased prevalence of potentially inappropriate medication in the Indonesian geriatric population visiting primary care facilities.Therapeutics and clinical risk management · 2018Article
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3 authors.
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Abstract
backgroundPotentially inappropriate medication (PIM) use in the elderly is associated with increased risk of adverse drug reactions (ADRs), but there is limited information regarding PIM use in the intensive care unit (ICU) setting.
objectiveThe aim of the study is to describe the prevalence and factors associated with the use of PIM and the occurrence of PIM-related adverse reactions in the critically ill elderly.
methodsThis study enrolled all critically ill older adults (60 years or more) admitted to medical or cardiovascular ICUs between January and December 2013, in a large tertiary teaching hospital. For all patients, clinical pharmacists listed the medications given during the ICU stay and data on drugs were analyzed using 2012 Beers Criteria, to identify the prevalence of PIM. For each identified PIM the medical records were analyzed to evaluate factors associated with its use. The frequency of ADRs and, the causal relationship between PIM and the ADRs identified were also evaluated through review of medical records.
resultsAccording to 2012 Beers Criteria, 98.2% of elderly patients used at least one PIM (n=599), of which 24.8% were newly started in the ICUs. In 29.6% of PIMs, there was a clinical circumstance that justified their prescription. The number of PIMs was associated with ICU length of stay and total number of medications. There was at least one ADR identified in 17.8% of patients; more than 40% were attributed to PIM, but there was no statistical association.
conclusionsThere is a high prevalence of PIM used in acutely ill older people, but they do not seem to be the major cause of adverse drug reactions in this population. Although many PIMs had a clinical circumstance that led to their prescription during the course of ICU hospitalization, many were still present upon hospital discharge. Therefore, prescription of PIMs should be minimized to improve the safety of elderly patients.
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