ReviewAnnals of gastroenterology2017
Management of complex perianal Crohn's disease.
Review in Annals of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04791878 (A Phase I Study of Adult Allogeneic Bone Marrow Derived Mesenchymal Stem Cells for Pediatric Perianal Fistulizing Crohn's Disease), which is not on this map. Cited by 49 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase I Study of Adult Allogeneic Bone Marrow Derived Mesenchymal Stem Cells for Pediatric Perianal Fistulizing Crohn's Disease
Who cites it
49 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Impact of Seton Use on Clinical, Patient-Reported, and Healthcare Resource Utilization Outcomes in Complex Crohn's Perianal Fistulas: A Systematic Literature Review.Inflammatory bowel diseases · 2025Pooled it
- A systematic review of outcome measurement instruments used in pouch anal and vaginal fistulae: a COSMIN-based analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Pooled it
- Predictive value of blood concentration of biologics on endoscopic inactivity in inflammatory bowel disease: A systematic review.World journal of gastroenterology · 2021Pooled it
- Burden and outcomes for complex perianal fistulas in Crohn's disease: Systematic review.World journal of gastroenterology · 2018Pooled it
- Intraoperative Autologous Platelet-Rich Stroma Injection as Add-On to Fistula Curettage and Closure of the Internal Orifice Demonstrates a Favorable Outcome in Long-Term in Patients Suffering from Therapy-Refractory Perianal Fistulizing Crohn's Disease.Inflammatory bowel diseases · 2025Trial
- Darvadstrocel for Complex Perianal Fistulas in Japanese Adults with Crohn's Disease: A Phase 3 Study.Journal of Crohn's & colitis · 2023Trial
- Efficacy of Adalimumab for Treatment of Perianal Fistula in Children with Moderately to Severely Active Crohn's Disease: Results from IMAgINE 1 and IMAgINE 2.Journal of Crohn's & colitis · 2018Trial
- Letter: Upadacitinib in Perianal Crohn's Disease: Does Clinical Closure Reflect True Remission?Alimentary pharmacology & therapeutics · 2026Article
- Clinical Trial Endpoints for Perianal Fistulizing Crohn's Disease.The American journal of gastroenterology · 2026Review
- Impaired keratinization activity in perianal Crohn's fistulas is associated with poor prognosis.Journal of Crohn's & colitis · 2026Article
- Subcutaneous infliximab in the treatment of patients with perianal fistulizing Crohn's disease: current evidence and emerging roles.Therapeutic advances in gastroenterology · 2026Review
- Analysis of the current status of research on perianal lesions associated with Crohn's disease: a bibliometric and visualization analysis.Frontiers in surgery · 2026Article
- Non-Fistulizing Perianal Disease in Crohn's Disease: Clinical Significance, Pathogenesis, and Management Strategies.Journal of clinical medicine · 2025Review
- The Use of Adipose-Derived Stem Cells for the Treatment of Complex Postoperative Enterocutaneous Fistulas: A Preliminary Case Series Study.Medicina (Kaunas, Lithuania) · 2025Observational
- Epidemiology, treatment patterns, and associated risk factors in perianal fistulizing Crohn's disease: A systematic literature review.World journal of gastrointestinal surgery · 2025Article
- Current practice and innovations in diagnosing perianal fistulizing Crohn's disease (pfCD): a narrative review.Techniques in coloproctology · 2025Review
- Enterocutaneous Fistula in a Patient with Crohn's Disease After Internalization of a Foreign Body into the Gastrointestinal Tract.Journal of clinical medicine · 2025Article
- How to Approach the Difficult Perineum in Crohn's Disease.Clinics in colon and rectal surgery · 2025Review
- Long-term outcomes of 'temporary' defunctioning in patients with severe perianal Crohn's disease.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with Crohn's disease often develop perianal disease, successfully managed in most cases. However, its most aggressive form, complex perianal disease, is associated with high morbidity and a significant impairment in patients' quality of life. The aim of this review is to provide an updated approach to this condition, reviewing aspects of its epidemiology, diagnosis and therapeutic alternatives. Emerging treatment options are also discussed. A multidisciplinary assessment of these patients with a coordinated medical and surgical approach is crucial.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.