ArticleOperative techniques in orthopaedics2016
Cell and Biologic-Based Treatment of Flexor Tendon Injuries.
Article in Operative techniques in orthopaedics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Pooled it
- Use of a bioresorbable polylactide sheet (OrthoWrapBMC musculoskeletal disorders · 2025Trial
- Management of infected flexor tendon injuries: A narrative review.Journal of hand and microsurgery · 2026Review
- Therapeutic effect of sustained release of aloe emodin via novel grafted polymer in electrospun nanofiber membranes on peritendinous adhesions.Frontiers in bioengineering and biotechnology · 2026Article
- Progress in Polysaccharide-Based Hydrogels for Preventing Postoperative Adhesions: A Review.Gels (Basel, Switzerland) · 2025Review
- Mechanisms and new advances in the efficacy of plant active ingredients in tendon-bone healing.Journal of orthopaedic surgery and research · 2025Review
- Engineering a functional ACL reconstruction graft containing a triphasic enthesis-like structure in bone tunnel for the enhancement of graft-to-bone integration.Journal of orthopaedic translation · 2024Article
- Highly oriented hydrogels for tissue regeneration: design strategies, cellular mechanisms, and biomedical applications.Theranostics · 2024Review
- Extracellular Vesicles From Primed Adipose-Derived Stem Cells Enhance Achilles Tendon Repair by Reducing Inflammation and Promoting Intrinsic Healing.Stem cells (Dayton, Ohio) · 2023Article
- Bioactive Nanostructured Scaffold-Based Approach for Tendon and Ligament Tissue Engineering.Nanomaterials (Basel, Switzerland) · 2023Review
- Risk factors associated with tendon adhesions after hand tendon repair.Frontiers in surgery · 2023Article
- Engineering an enthesis-like graft for rotator cuff repair: An approach to fabricate highly biomimetic scaffold capable of zone-specifically releasing stem cell differentiation inducers.Bioactive materials · 2022Article
- Improving flexor tendon gliding by using the combination of carboxymethylcellulose-polyethylene oxide on murine model.Experimental and therapeutic medicine · 2022Article
- A critical review on polydopamine surface-modified scaffolds in musculoskeletal regeneration.Frontiers in bioengineering and biotechnology · 2022Review
- Proceed with Caution: Mouse Deep Digit Flexor Tendon Injury Model.Plastic and reconstructive surgery. Global open · 2021Article
- Improved tendon healing by a combination of Tanshinone IIA and miR-29b inhibitor treatment through preventing tendon adhesion and enhancing tendon strength.International journal of medical sciences · 2020Article
- Synergistic Therapy of Celecoxib-Loaded Magnetism-Responsive Hydrogel for Tendon Tissue Injuries.Frontiers in bioengineering and biotechnology · 2020Article
- Stem cell-derived extracellular vesicles attenuate the early inflammatory response after tendon injury and repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Absence of estrogen receptor beta leads to abnormal adipogenesis during early tendon healing by an up-regulation of PPARγ signalling.Journal of cellular and molecular medicine · 2019Article
- Flexor Tendon: Development, Healing, Adhesion Formation, and Contributing Growth Factors.Plastic and reconstructive surgery · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The two primary factors leading to poor clinical results after intrasynovial tendon repair are adhesion formation within the digital sheath and repair-site elongation and rupture. As the outcomes following modern tendon multi-strand repair and controlled rehabilitation techniques are often unsatisfactory, alternative approaches, such as the application of growth factors and mesenchymal stem cells (MSCs), have become increasingly attractive treatment options. Successful biological therapies require carefully controlled spatiotemporal delivery of cells, growth factors, and biocompatible scaffold matrices in order to simultaneously (1) promote matrix synthesis at the tendon repair site leading to increased biomechanical strength and stiffness and (2) suppress matrix synthesis along the tendon surface and synovial sheath preventing adhesion formation. This review summarizes recent cell and biologic-based experimental treatments for flexor tendon injury, with an emphasis on large animal translational studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.