Evidence map›Paper›PMID 28042152›Full record

Trial reportThe Canadian veterinary journal = La revue veterinaire canadienne2017

A comparison between maropitant and metoclopramide for the prevention of morphine-induced nausea and vomiting in dogs.

Augusto M Lorenzutti, Manuel Martín-Flores, Nicolás J Litterio, Martín A Himelfarb, Sergio H Invaldi, María P Zarazaga

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC
In one paragraph

Trial report in The Canadian veterinary journal = La revue veterinaire canadienne, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Incidence of Post-Sedation Emesis in Cynomolgus (Animals : an open access journal from MDPI · 2025
    Article
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  14. Spotlight on the perioperative use of maropitant citrate.Veterinary medicine (Auckland, N.Z.) · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Augusto M LorenzuttiCátedra de Farmacología y Toxicología, Facultad de Ciencias Agropecuarias, Universidad Católica de Córdoba, Argentina (Lorenzutti, Litterio, Himelfarb, Invaldi, Zarazaga); Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA (Martin-Flores).
Manuel Martín-FloresCátedra de Farmacología y Toxicología, Facultad de Ciencias Agropecuarias, Universidad Católica de Córdoba, Argentina (Lorenzutti, Litterio, Himelfarb, Invaldi, Zarazaga); Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA (Martin-Flores).
Nicolás J LitterioCátedra de Farmacología y Toxicología, Facultad de Ciencias Agropecuarias, Universidad Católica de Córdoba, Argentina (Lorenzutti, Litterio, Himelfarb, Invaldi, Zarazaga); Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA (Martin-Flores).
Martín A HimelfarbCátedra de Farmacología y Toxicología, Facultad de Ciencias Agropecuarias, Universidad Católica de Córdoba, Argentina (Lorenzutti, Litterio, Himelfarb, Invaldi, Zarazaga); Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA (Martin-Flores).
Sergio H InvaldiCátedra de Farmacología y Toxicología, Facultad de Ciencias Agropecuarias, Universidad Católica de Córdoba, Argentina (Lorenzutti, Litterio, Himelfarb, Invaldi, Zarazaga); Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA (Martin-Flores).
María P ZarazagaCátedra de Farmacología y Toxicología, Facultad de Ciencias Agropecuarias, Universidad Católica de Córdoba, Argentina (Lorenzutti, Litterio, Himelfarb, Invaldi, Zarazaga); Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA (Martin-Flores).
Universidad Católica de Córdoba · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Morphine is widely used as a preanesthetic agent in dogs, but it often produces signs of nausea and vomiting. Maropitant (MRP) and metoclopramide (MCP) prevent emesis attributable to the opioid agent apomorphine in dogs. We evaluated the antiemetic efficacy and the discomfort in response to SQ injection of MRP [1 mg/kg body weight (BW)], MCP (0.5 mg/kg BW), and normal saline (SAL; 0.1 mL/kg BW) administered to 63 dogs, 45 minutes prior to morphine (0.5 mg/kg BW) and acepromazine (0.05 mg/kg BW). Dogs were observed for signs of nausea (ptyalism, lip licking, and increased swallowing) and vomiting for 30 minutes after morphine/acepromazine. The incidence of emesis was 0% for MRP, 38% for MCP, and 71% for SAL (

Indexed as

Analgesics, OpioidAnimalsAntiemeticsDog DiseasesDogsFemaleHysterectomyMaleMetoclopramideMorphineNauseaOrchiectomyOvariectomyQuinuclidinesVomitingAnalgesics, OpioidAntiemeticsmaropitantMetoclopramideMorphineQuinuclidines

Identifiers

PMID28042152
PMCPMC5157735
OpenAlexW2584272983

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.