Evidence map›Paper›PMID 28042079›Full record

ArticleJournal of pain and symptom management2017

Association Between Multi-frequency Phase Angle and Survival in Patients With Advanced Cancer.

David Hui, Rony Dev, Lindsay Pimental, Minjeong Park, Maria A Cerana, Diane Liu, Eduardo Bruera

Abstract read
In one paragraph

Article in Journal of pain and symptom management, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Phase angle and mortality: a systematic review.European journal of clinical nutrition · 2019
    Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Diagnostic and prognostic utility of phase angle in patients with cancer.Reviews in endocrine & metabolic disorders · 2023
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Observational
  17. Observational
  18. BIOELECTRICAL VECTOR ANALYSIS IN OBESE ADOLESCENTS.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2020
    Observational
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David HuiDepartment of Palliative Care and Rehabilitation Medicine, MD Anderson Cancer Center, Houston, USA. Electronic address: dhui@mdanderson.org.
Rony DevDepartment of Palliative Care and Rehabilitation Medicine, MD Anderson Cancer Center, Houston, USA.
Lindsay PimentalDepartment of Palliative Care and Rehabilitation Medicine, MD Anderson Cancer Center, Houston, USA.
Minjeong ParkDepartment of Biostatistics, MD Anderson Cancer Center, Houston, USA.
Maria A CeranaDepartment of Palliative Care and Rehabilitation Medicine, MD Anderson Cancer Center, Houston, USA.
Diane LiuDepartment of Biostatistics, MD Anderson Cancer Center, Houston, USA.
Eduardo BrueraDepartment of Palliative Care and Rehabilitation Medicine, MD Anderson Cancer Center, Houston, USA.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Kathrin Milbury · 1985 to 2026
$290.8M
Adjuvant Lorazepam for Agitated Delirium in the Palliative Care UnitR21CA186000 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HUI, DAVID · 2015 to 2016
$399k
NCI NIH HHS P30 CA016672NCI NIH HHS R21 CA186000
6 · The paper itself

Abstract

contextThe ability to predict survival accurately has implications in clinical decision making.

objectivesWe determined the association of phase angle obtained from multi-frequency bioelectric impedance analysis with overall survival in patients with advanced cancer.

methodsWe included consecutive patients with advanced cancer who had an outpatient palliative care consultation. Multi-frequency bioelectric impedance analysis assessed phase angle at three different frequencies (5/50/250 kHz) on each hemibody (right/left). Survival analysis was conducted using the Kaplan-Meier method, log-rank test, and multivariate Cox regression analysis.

resultsAmong 366 patients, the median overall survival was 250 days (95% confidence interval 191-303 days). The mean phase angle for 5, 50, and 250 kHz were 2.2°, 4.4°, and 4.2° on the right and 2.0°, 4.2° and 4.1° on the left, respectively. For all six phase angles, a lower value was significantly associated with a poorer overall survival (P < 0.001). After adjusting for cancer type, performance status, weight loss, and inflammatory markers, phase angle remained independently associated with overall survival (hazard ratio 0.85 per degree increase, 95% confidence interval 0.72-0.99; P = 0.048).

conclusionPhase angle represents a novel objective prognostic factor in outpatient palliative cancer care setting, regardless of frequency and body sides.

Indexed as

Electric ImpedanceElectrodiagnosisAdultAgedAged, 80 and overBody CompositionFemaleHumansMaleMiddle AgedMultivariate AnalysisNeoplasmsPrognosisRetrospective StudiesSurvival AnalysisYoung AdultElectric impedanceforecastingneoplasmspalliative careprognosissurvival

Identifiers

PMID28042079
PMCPMC5337125

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.