ArticleCell stem cell2017
A Quiescent Bcl11b High Stem Cell Population Is Required for Maintenance of the Mammary Gland.
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Article in Cell stem cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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68citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
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Who cites it
68 citing papers in PubMed, 107 citations in OpenAlex.
- Carmn sustains basal stemness in exocrine glands and CTND1-mediated Wnt signaling in mammary tissue.EMBO reports · 2026Article
- BCL11B predetermines a persister state in breast cancer that is reversed by TNFα.Science advances · 2026Article
- Establishing a long-term versatile culture system for functional mouse mammary organoids from single cells.Nature protocols · 2026Review
- Branching out: the diverse roles of stem and progenitor cells in mammary gland development.Journal of mammary gland biology and neoplasia · 2026Review
- Canonical BAF chromatin remodeling complex specifies stem cell fate via cell-type-specific co-factor recruitment.Nature communications · 2026Article
- LMO2 Regulates Epithelial-Mesenchymal Plasticity of Mammary Epithelial Cells.Journal of mammary gland biology and neoplasia · 2026Article
- The transcription factor BCL11B drives NK cell cytotoxicity and antitumor activity.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Defining breast epithelial cell types in the single-cell era.Developmental cell · 2025Review
- Article
- CXCR4Nature communications · 2025Article
- Distinct mammary stem cells orchestrate long-term homeostasis of adult mammary gland.Cell discovery · 2025Article
- Concomitant loss of TET2 and TET3 results in T cell expansion and genomic instability in mice.Communications biology · 2024Article
- BMP suppresses Wnt signaling via the Bcl11b-regulated NuRD complex to maintain intestinal stem cells.The EMBO journal · 2024Article
- Article
- Pregnancy Reduces Il33+ Hybrid Progenitor Accumulation in the Aged Mammary Gland.bioRxiv : the preprint server for biology · 2024Article
- Progressive senescence programs induce intrinsic vulnerability to aging-related female breast cancer.Nature communications · 2024Article
- Droplet-based proteomics reveals CD36 as a marker for progenitors in mammary basal epithelium.Cell reports methods · 2024Article
- A common regulatory haplotype doubles lactoferrin concentration in milk.Genetics, selection, evolution : GSE · 2024Article
- Reconstruction of dynamic mammary mini gland in vitro for normal physiology and oncogenesis.Nature methods · 2023Article
- FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters.The Journal of clinical investigation · 2023Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
21 authors at 3 institutions in 2 countries.
Shang CaiInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Tomer KaliskyDepartment of Bioengineering, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Debashis SahooInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA; Department of Pediatrics, Department of Computer Science and Engineering, University of California San Diego, San Diego, CA 92123-0984, USA.
Piero DalerbaInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA; Department of Pathology & Cell Biology, Columbia University, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA.
Weiguo FengInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA; Cancer Institute, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Yuan LinInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA; Cancer Institute, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Dalong QianInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Angela KongInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Jeffrey YuInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Flora WangInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Elizabeth Y ChenInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Ferenc A ScheerenInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Angera H KuoInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Shaheen S SikandarInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Shigeo HisamoriInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Linda J van WeeleInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Diane HeiserInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Sopheak SimInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Jessica LamInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Stephen QuakeDepartment of Bioengineering, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Michael F ClarkeInstitute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA. Electronic address: mfclarke@stanford.edu.
Stanford University · USCalifornia Institute for Regenerative Medicine · USColumbia University Irving Medical Center · US
Funding
therapeutic Targeting of CD47 on Human Leukemia and Other Cancer Stem CellsP01CA139490 · NCI · STANFORD UNIVERSITY · PI CLARKE, MICHAEL · 2009 to 2013
$8.7MSelf-Renewal of Normal and Leukemic Stem CellsR01CA100225 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CLARKE, MICHAEL · 2004 to 2015
$2.9MCellular hierachy of ER- breast cancers in different ethnic groupsU01CA154209 · NCI · STANFORD UNIVERSITY · PI CLARKE, MICHAEL · 2010 to 2014
$2.5MApplication of Boolean Networks to discover stem and progenitor cellsR00CA151673 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SAHOO, DEBASHIS · 2014 to 2016
$717kNCI NIH HHS P01 CA139490NCI NIH HHS R00 CA151673NCI NIH HHS R01 CA100225NCI NIH HHS U01 CA154209
Abstract
Stem cells in many tissues sustain themselves by entering a quiescent state to avoid genomic insults and to prevent exhaustion caused by excessive proliferation. In the mammary gland, the identity and characteristics of quiescent epithelial stem cells are not clear. Here, we identify a quiescent mammary epithelial cell population expressing high levels of Bcl11b and located at the interface between luminal and basal cells. Bcl11b
Indexed as
Cell CycleAnimalsAntigens, CDCell LineageCell ProliferationCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p21Epithelial CellsFemaleGene DeletionHomeostasisMammary Glands, AnimalMice, Inbred C57BLMice, KnockoutRegenerationRepressor ProteinsAntigens, CDBcl11b protein, mouseCdkn1a protein, mouseCdkn2a protein, mouseCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p21Repressor ProteinsTumor Suppressor Proteinsquiescencestem cell exhaustion
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.