ArticleCurrent biology : CB2017
PIF4 Coordinates Thermosensory Growth and Immunity in Arabidopsis.
Article in Current biology : CB, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed.
- PIF4 enhances temperature-independent tolerance to TSWV in Nicotiana benthamiana.Scientific reports · 2026Article
- CUL3Science advances · 2026Article
- Threshold-dependent negative autoregulation of PIF4 gene expression optimizes growth and fitness in Arabidopsis.PLoS genetics · 2025Article
- BBX24 and BBX25 antagonize the function of thermosensor ELF3 to promote PIF4-mediated thermomorphogenesis in Arabidopsis.Plant communications · 2025Article
- Transcriptome Analysis of Cabbage Near-Isogenic Lines Reveals the Involvement of the Plant Defensin GeneInternational journal of molecular sciences · 2025Article
- Genome scans capture key adaptation and historical hybridization signatures in tetraploid wheat.The plant genome · 2025Article
- Integrating temperature into the Arabidopsis circadian system.Npj biological timing and sleep · 2025Review
- MPK4-mediated phosphorylation of PHYTOCHROME INTERACTING FACTOR4 controls thermosensing by regulating histone variant H2A.Z deposition.The Plant cell · 2024Article
- Arabidopsis MORC1 and MED9 Interact to Regulate Defense Gene Expression and Plant Fitness.The plant pathology journal · 2024Article
- Using a thermal gradient table to study plant temperature signalling and response across a temperature spectrum.Plant methods · 2024Article
- Functions of Phytochrome Interacting Factors (PIFs) in Adapting Plants to Biotic and Abiotic Stresses.International journal of molecular sciences · 2024Review
- Near-infrared light and PIF4 promote plant antiviral defense by enhancing RNA interference.Plant communications · 2024Article
- PIF transcription factors-versatile plant epigenome landscapers.Frontiers in epigenetics and epigenomics · 2024Review
- PYRIDOX(AM)INE 5'-PHOSPHATE OXIDASE3 of Arabidopsis thaliana maintains carbon/nitrogen balance in distinct environmental conditions.Plant physiology · 2023Article
- Review
- Functions of Plant Phytochrome Signaling Pathways in Adaptation to Diverse Stresses.International journal of molecular sciences · 2023Review
- Differential CaKAN3-CaHSF8 associations underlie distinct immune and heat responses under high temperature and high humidity conditions.Nature communications · 2023Article
- The non-coding RNA SVALKA locus produces a cis-natural antisense transcript that negatively regulates the expression of CBF1 and biomass production at normal temperatures.Plant communications · 2023Article
- Novel exotic alleles of EARLY FLOWERING 3 determine plant development in barley.Journal of experimental botany · 2023Article
- The Mediator complex subunit MED25 interacts with HDA9 and PIF4 to regulate thermomorphogenesis.Plant physiology · 2023Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Temperature is a key seasonal signal that shapes plant growth. Elevated ambient temperature accelerates growth and developmental transitions [1] while compromising plant defenses, leading to increased susceptibility [2, 3]. Suppression of immunity at elevated temperature is at the interface of trade-off between growth and defense [2, 4]. Climate change and the increase in average growth-season temperatures threaten biodiversity and food security [5, 6]. Despite its significance, the molecular mechanisms that link thermosensory growth and defense responses are not known. Here we show that PHYTOCHROME INTERACTING FACTOR 4 (PIF4)-mediated thermosensory growth and architecture adaptations are directly linked to suppression of immunity at elevated temperature. PIF4 positively regulates growth and development and negatively regulates immunity. We also show that natural variation of PIF4-mediated temperature response underlies variation in the balance between growth and defense among Arabidopsis natural strains. Importantly, we find that modulation of PIF4 function alters temperature sensitivity of defense. Perturbation of PIF4-mediated growth has resulted in temperature-resilient disease resistance. This study reveals a molecular link between thermosensory growth and immunity in plants. Elucidation of the molecular mechanisms that define environmental signal integration is key to the development of novel strategies for breeding temperature-resilient disease resistance in crops.
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