ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2017
Bipolar Patients with Vascular Risk Display a Steeper Age-Related Negative Slope in Inhibitory Performance but Not Processing Speed: A Preliminary Study.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Cognitive performance in older-age bipolar disorder: Investigating psychiatric characteristics, cardiovascular burden and psychotropic medication.Acta psychiatrica Scandinavica · 2021Article
- Steeper Slope of Age-Related Changes in White Matter Microstructure and Processing Speed in Bipolar Disorder.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2017Article
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Authors and funding
2 authors.
Funding
Abstract
objectiveBipolar disorder (BD) is associated with cognitive deficits, yet little is known about associations between cognition, vascular risk (VR), and age in this population. This study investigated whether BD patients with VR demonstrate stronger apparent age-related decline in inhibitory performance and processing speed (PS).
methodsA full medical history was obtained for 34 euthymic BD and 41 healthy comparison (HC) individuals. The Delis-Kaplan Executive Functions Color Word Interference Subtests were administered to all participants to assess for inhibitory performance (condition 3) and PS (conditions 1 and 2). VR positive (VRPos) and VR negative (VRNeg) groups were created based on the presence of one or more VR factors.
resultsVRPos-BD participants demonstrated significantly worse inhibitory performance with older age, whereas age and inhibition were not significantly related in the VRPos-HC group or in those who were VRNeg. The same was not true for PS.
conclusionBD patients with VR may also be at risk for greater decline in inhibitory performance, but not PS, with age. Longitudinal studies are needed to further investigate the contributions of VR to cognitive decline among older BD patients.
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