Evidence map›Paper›PMID 28041666›Full record

ArticleThe Journal of pediatrics2017

Prediabetes in Pediatric Recipients of Liver Transplant: Mechanism and Risk Factors.

Emily R Perito, Robert H Lustig, Philip Rosenthal

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Emily R PeritoDepartment of Pediatrics, University of California, San Francisco Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA; Department of Epidemiology and Biostatistics, University of California, San Francisco Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA. Electronic address: emily.perito@ucsf.edu.
Robert H LustigDepartment of Pediatrics, University of California, San Francisco Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA.
Philip RosenthalDepartment of Pediatrics, University of California, San Francisco Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA; Department of Surgery, University of California, San Francisco Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA.
University of California, San Francisco · USUCSF Benioff Children's Hospital · US

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7M
UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
TRAINING PROGRAM IN PEDIATRIC GASTROENTEROLOGY/NUTRITIONT32DK007762 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI James Bayrer · 1998 to 2026
$7.3M
Metabolic Syndrome after Pediatric Liver Transplant: Causes and ConsequencesK23DK099253 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PERITO, EMILY ROTHBAUM · 2014 to 2018
$938k
NCATS NIH HHS UL1 TR000004NIDDK NIH HHS K23 DK099253NIDDK NIH HHS P30 DK026743NIDDK NIH HHS P30 DK098722NIDDK NIH HHS T32 DK007762
6 · The paper itself

Abstract

objectiveTo investigate the role of calcineurin inhibitor exposure and states of insulin resistance-obesity and adolescence-in prediabetes after pediatric liver transplant via oral glucose tolerance testing, which previously has not been done systematically in these at-risk youths. STUDY

designThis was a cross-sectional study of 81 pediatric recipients of liver transplant. Prediabetes was defined as impaired glucose tolerance (IGT; glucose ≥140 mg/dL at 2 hours) or impaired fasting glucose (IFG, ≥100 mg/dL). Corrected insulin response (CIR) was calculated as measure of insulin secretion, corrected for glucose (CIR

resultsSubjects were aged 8.1-30.0 years and 1.1-24.7 years post-transplant; 44% had prediabetes-27% IGT, 14% IFG, and 3% both. IGT was characterized by insulin hyposecretion, with lower CIR

conclusionIGT after pediatric liver transplant is driven by inadequate insulin secretion. It is quite common but not detectable with fasting laboratory values-the screening recommended by current guidelines. Calcineurin inhibitors suppress insulin secretion in these patients in a dose-dependent manner. Given the recent focus on long-term outcomes and immunosuppression withdrawal in these children, longitudinal studies are warranted to investigate whether IGT is reversible with calcineurin inhibitor minimization.

Indexed as

Transplant RecipientsAdolescentAdultAge FactorsBlood GlucoseChildCross-Sectional StudiesFemaleGlucose Tolerance TestGraft RejectionGraft SurvivalHumansIncidenceInsulinInsulin ResistanceInsulin SecretionBlood GlucoseInsulinchildrenimmunosuppressionimpaired glucose toleranceliver transplantationmetabolic syndrome

Identifiers

PMID28041666
PMCPMC5328850
OpenAlexW2566144931

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.