Evidence map›Paper›PMID 28040891›Full record

ArticleBiochemistry2017

Quantification of the d-Ala-d-Lac-Terminated Peptidoglycan Structure in Vancomycin-Resistant Enterococcus faecalis Using a Combined Solid-State Nuclear Magnetic Resonance and Mass Spectrometry Analysis.

James D Chang, Erin E Foster, Hao Yang, Sung Joon Kim

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Genome-wide analysis ofJournal of bacteriology · 2025
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Surface proteins and the formation of biofilms by Staphylococcus aureus.Biochimica et biophysica acta. Biomembranes · 2018
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

James D ChangDepartment of Chemistry and Biochemistry, Baylor University , Waco, Texas 76798, United States.
Erin E FosterDepartment of Chemistry and Biochemistry, Baylor University , Waco, Texas 76798, United States.
Hao YangDepartment of Chemistry, Washington University , St. Louis, Missouri 63130, United States.
Sung Joon KimDepartment of Chemistry and Biochemistry, Baylor University , Waco, Texas 76798, United States.ORCID 0000-0002-2007-6606
Baylor University · USWashington University in St. Louis · US

Funding

GLYCOPEPTIDE COMPLEXES WITH BACTERIAL CELL WALLS BY REDORR01GM116130 · NIGMS · WASHINGTON UNIVERSITY · PI PATTI, GARY J · 2015 to 2018
$1.2M
NIGMS NIH HHS R01 GM116130
6 · The paper itself

Abstract

Induction of vancomycin resistance in vancomycin-resistant enterococci (VRE) involves replacement of the d-Ala-d-Ala terminus of peptidoglycan (PG) stems with d-Ala-d-Lac, dramatically reducing the binding affinity of vancomycin for lipid II. Effects from vancomycin resistance induction in Enterococcus faecalis (ATCC 51299) were characterized using a combined solid-state nuclear magnetic resonance (NMR) and liquid chromatography-mass spectrometry (LC-MS) analysis. Solid-state NMR directly measured the total amounts of d-Lac and l,d-Ala metabolized from [2-

Indexed as

AlanineAnti-Bacterial AgentsCell WallDipeptidesEndopeptidasesEnterococcus faecalisLactatesMagnetic Resonance SpectroscopyMass SpectrometryPeptidoglycanUridine Diphosphate N-Acetylmuramic AcidVancomycinVancomycin ResistanceAlaninealanylalaninealanyllactateAnti-Bacterial AgentsDipeptidesEndopeptidasesLactatesmuramyl-NAc-(pentapeptide)pyrophosphoryl-undecaprenolmutanolysinPeptidoglycanUridine Diphosphate N-Acetylmuramic AcidVancomycin

Identifiers

PMID28040891
PMCPMC6906607
OpenAlexW2567324748

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.