SynthesisInternational journal of clinical pharmacy2017
Incidence of bradycardia in pediatric patients receiving dexmedetomidine anesthesia: a meta-analysis.
Synthesis in International journal of clinical pharmacy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Impact of intraoperative dexmedetomidine on postoperative outcomes in shoulder arthroscopy: a systematic review and meta-analysis.BMC anesthesiology · 2026Pooled it
- Intranasal esketamine plus dexmedetomidine versus dexmedetomidine alone for emergence delirium in pediatric patients: a systematic review and meta-analysis of randomized controlled trials.BMC anesthesiology · 2026Pooled it
- Dexmedetomidine with lidocaine topical anesthesia reduces emergence agitation and postoperative pain after pediatric tonsillectomy.Scientific reports · 2026Trial
- Comparison of Intranasal Dexmedetomidine and Oral Midazolam for Premedication in Pediatric Dental Patients under General Anesthesia: A Randomised Clinical Trial.BioMed research international · 2020Trial
- Effect of dexmedetomidine for attenuation of propofol injection pain in electroconvulsive therapy: a randomized controlled study.Journal of anesthesia · 2018Trial
- Dexmedetomidine aggravates hypotension following mesenteric traction during total gastrectomy: a randomized controlled trial.Annals of Saudi medicineTrial
- The Efficacy and Safety of Intranasal Dexmedetomidine Spray Followed by Nitrous Oxide for Paediatric Oral Procedures.International dental journal · 2026Article
- Observational
- Sedation and analgesia strategies in the neuro intensive care unit.World journal of critical care medicine · 2025Review
- Clinically significant bradycardia in children with respiratory syncytial virus bronchiolitis receiving dexmedetomidine: effect modification by mechanical ventilation.BMJ paediatrics open · 2025Article
- Dexmedetomidine: Shifting Paradigms in Neonatal Sedation and Pain Control.Children (Basel, Switzerland) · 2025Review
- Comparative evaluation of intravenous versus intranasal dexmedetomidine on emergence delirium and hemodynamics in pediatric patients undergoing adenotonsillectomy: a randomized controlled trial.Frontiers in pharmacology · 2025Article
- Prevalence of Bradycardia After Induction of General Anesthesia and Associated Factors Among Surgical Pediatric Patients. A Prospective Observational Study.Pediatric health, medicine and therapeutics · 2023Article
- Improved postoperative recovery profile in pediatric oral rehabilitation with low-dose dexmedetomidine as an opioid substitute for general anesthesia: a randomized double-blind clinical trial.Journal of dental anesthesia and pain medicine · 2022Article
- Safety of Dexmedetomidine as an Alternative Pediatric Magnetic Resonance Imaging (MRI) Sedative: A Retrospective Single-Center Study.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Circulating microRNA-30a-5p, microRNA-101-3p, microRNA-140-3p and microRNA-141-3p as potential biomarkers for dexmedetomidine response in pediatric patients.European journal of clinical pharmacology · 2021Article
- Values of heart rate at rest in children and adults living at different altitudes in the Andes.PloS one · 2019Article
- Dexmedetomidine as an Adjunct to Treat Anticholinergic Toxidrome in Children.Global pediatric health · 2017Article
- A non-randomized controlled study of total intravenous anesthesia regimens for magnetic resonance imaging studies in children.Journal of anaesthesiology, clinical pharmacologyArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Dexmedetomidine, an α2-receptor agonist, provides potent sedation, analgesia, and anxiolysis without respiratory depression and is used in a variety of surgical and procedural situations. Aim of the review The aim of this study was to estimate the incidence of bradycardia in pediatric patients who received dexmedetomidine as a sole agent for any procedural, intensive care or surgical sedation. Method Literature was searched in electronic databases and studies were selected by following pre-determined eligibility criteria. Meta-analyses were carried out by pooling the percent incidence of bradycardia to attain a weighted overall effect size. Age-wise subgroup analyses and meta-regression analyses for the identification of factors affecting the incidence were also performed. Results Data of 2835 patients from 21 studies were included. The mean age was 62.21 ± 35.68 months. Initial, maintenance and total doses of dexmedetomidine (mean ± standard deviation) were 1.63 ± 0.33 μg/kg body weight, 0.86 ± 0.68 μg/kg/h, and 26.7 ± 20.8 μg/kg. The overall incidence of bradycardia (95% confidence interval) was 3.067 (2.863, 3.270)%; P < 0.0001. However, range was wider (0-22%) with 9 studies observed 0% incidence. The mean change in the heart rate was -17.26 (-21.60, -12.92); P < 0.00001. In the meta-regression analyses, age, body weight and dexmedetomidine dose were not significantly associated with the incidence of bradycardia. The minimum heart rate observed during the dexmedetomidine treatment period was positively associated with baseline heart rate. Conclusion Incidence of bradycardia in dexmedetomidine treated pediatric patients is 3%.
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Registered trials
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