Evidence map›Paper›PMID 28040784›Full record

ArticleG3 (Bethesda, Md.)2017

Genetic Analysis of the Lambda Spanins Rz and Rz1: Identification of Functional Domains.

Jesse Cahill, Manoj Rajaure, Chandler O'Leary, Jordan Sloan, Armando Marrufo, Ashley Holt, Aneesha Kulkarni, Oscar Hernandez, Ry Young

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. The Lysis cassette of jumbophage PhiKZ.Scientific reports · 2026
    Article
  3. The Lysis Cassette of Jumbophage phiKZ.bioRxiv : the preprint server for biology · 2025
    Article
  4. Review
  5. Review
  6. Identifying components of theJournal of bacteriology · 2024
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Phage Lysis: Multiple Genes for Multiple Barriers.Advances in virus research · 2019
    Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jesse CahillCenter for Phage Technology and Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843.ORCID 0000-0001-8387-9273
Manoj RajaureCenter for Phage Technology and Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843.
Chandler O'LearyCenter for Phage Technology and Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843.
Jordan SloanCenter for Phage Technology and Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843.
Armando MarrufoCenter for Phage Technology and Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843.
Ashley HoltCenter for Phage Technology and Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843.
Aneesha KulkarniCenter for Phage Technology and Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843.
Oscar HernandezCenter for Phage Technology and Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843.
Ry YoungCenter for Phage Technology and Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843 ryland@tamu.edu.
Texas A&M University · US

Funding

CONTROL OF VIRUS-INDUCED LYSISR01GM027099 · NIGMS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI YOUNG, RYLAND FLETCHER · 1985 to 2019
$4.6M
CONTROL OF VIRUS INDUCED LYSISR37GM027099 · NIGMS · TEXAS A&M UNIVERSITY SYSTEM · PI YOUNG, RYLAND F. · 1996 to 2005
$2.4M
NIGMS NIH HHS R01 GM027099NIGMS NIH HHS R37 GM027099
6 · The paper itself

Abstract

Coliphage lambda proteins Rz and Rz1 are the inner membrane and outer membrane subunits of the spanin complex-a heterotetramer that bridges the periplasm and is essential for the disruption of the outer membrane during phage lysis. Recent evidence suggests the spanin complex functions by fusing the inner and outer membrane. Here, we use a genetics approach to investigate and characterize determinants of spanin function. Because

Indexed as

Amino Acid SequenceBacteriophage lambdaEscherichia coliEscherichia coli ProteinsMembrane FusionMembrane ProteinsMutationViral ProteinsEscherichia coli Proteinsinner membrane protein, E coliMembrane ProteinsRz protein, bacteriophage lambdaViral ProteinsEscherichia colilysismembrane fusionphage

Identifiers

PMID28040784
PMCPMC5295617
OpenAlexW2584861000

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.